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Pre- and perinatal complications in relation to Tourette syndrome and co-occurring obsessive-compulsive disorder and attention-deficit/hyperactivity disorder

Authors
 Mohamed Abdulkadir  ;  Jay A. Tischfield  ;  Robert A. King  ;  Thomas V. Fernandez  ;  Lawrence W. Brown  ;  Keun-Ah Cheon  ;  Barbara J. Coffey  ;  Sebastian F.T.M. Bruijn  ;  Lonneke Elzerman  ;  Blanca Garcia-Delgar  ;  Donald L. Gilbert  ;  Dorothy E. Grice  ;  Julie Hagstrøm  ;  Tammy Hedderly  ;  Isobel Heyman  ;  Hyun Ju Hong  ;  Chaim Huyser  ;  Laura Ibanez-Gomez  ;  Young Key Kim  ;  Young-Shin Kim  ;  Yun-Joo Koh  ;  Sodahm Kook  ;  Samuel Kuperman  ;  Andreas Lamerz  ;  Bennett Leventhal  ;  Andrea G. Ludolph  ;  Marcos Madruga-Garrido  ;  Athanasios Maras  ;  Marieke D. Messchendorp  ;  Pablo Mir  ;  Astrid Morer  ;  Alexander M?nchau  ;  Tara L. Murphy  ;  Tha?ra J.C. Openneer  ;  Kerstin J. Plessen  ;  Judith J.G. Rath  ;  Veit Roessner  ;  Odette Fr?ndt  ;  Eun-Young Shin  ;  Deborah A. Sival  ;  Dong-Ho Song  ;  Jungeun Song  ;  Anne-Marie Stolte  ;  Jennifer T?bing  ;  Els van den Ban  ;  Frank Visscher  ;  Sina Wanderer  ;  Martin Woods  ;  Samuel H. Zinner  ;  Matthew W. State  ;  Gary A. Heiman  ;  Pieter J. Hoekstra  ;  , Andrea Dietrich 
Citation
 JOURNAL OF PSYCHIATRIC RESEARCH, Vol.82 : 126-135, 2016 
Journal Title
 JOURNAL OF PSYCHIATRIC RESEARCH 
ISSN
 0022-3956 
Issue Date
2016
MeSH
Adolescent ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Attention Deficit Disorder with Hyperactivity/diagnosis ; Attention Deficit Disorder with Hyperactivity/epidemiology* ; Case-Control Studies ; Child ; Child, Preschool ; Europe ; Female ; Humans ; Male ; Middle Aged ; Obsessive-Compulsive Disorder/diagnosis ; Obsessive-Compulsive Disorder/epidemiology* ; Parent-Child Relations ; Pregnancy ; Pregnancy Complications/epidemiology* ; Pregnancy Complications/physiopathology* ; Psychiatric Status Rating Scales ; Republic of Korea ; Retrospective Studies ; Severity of Illness Index ; Sex Factors ; Tic Disorders ; Tourette Syndrome/etiology* ; United States ; Young Adult
Keywords
Attention-deficit hyperactivity disorder ; Delivery ; Obsessive-compulsive disorder ; Pregnancy ; Prenatal ; Tourette syndrome
Abstract
Pre- and perinatal complications have been implicated in the onset and clinical expression of Tourette syndrome albeit with considerable inconsistencies across studies. Also, little is known about their role in co-occurring obsessive-compulsive disorder (OCD) and attention-deficit/hyperactivity disorder (ADHD) in individuals with a tic disorder. Therefore, we aimed to investigate the role of pre- and perinatal complications in relation to the presence and symptom severity of chronic tic disorder and co-occurring OCD and ADHD using data of 1113 participants from the Tourette International Collaborative Genetics study. This study included 586 participants with a chronic tic disorder and 527 unaffected family controls. We controlled for age and sex differences by creating propensity score matched subsamples for both case-control and within-case analyses. We found that premature birth (OR = 1.72) and morning sickness requiring medical attention (OR = 2.57) were associated with the presence of a chronic tic disorder. Also, the total number of pre- and perinatal complications was higher in those with a tic disorder (OR = 1.07). Furthermore, neonatal complications were related to the presence (OR = 1.46) and severity (b = 2.27) of co-occurring OCD and also to ADHD severity (b = 1.09). Delivery complications were only related to co-occurring OCD (OR = 1.49). We conclude that early exposure to adverse situations during pregnancy is related to the presence of chronic tic disorders. Exposure at a later stage, at birth or during the first weeks of life, appears to be associated with co-occurring OCD and ADHD.
Full Text
http://www.sciencedirect.com/science/article/pii/S002239561630156X?via%3Dihub
DOI
10.1016/j.jpsychires.2016.07.017
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Song, Dong Ho(송동호) ORCID logo https://orcid.org/0000-0002-9647-3130
Shin, Eun Young(신은영)
Cheon, Keun Ah(천근아) ORCID logo https://orcid.org/0000-0001-7113-9286
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152164
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