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Effects of high-frequency repetitive transcranial magnetic stimulation (rTMS) on spontaneously hypertensive rats, an animal model of attention-deficit/hyperactivity disorder

Authors
 Jungyun Ki  ;  Heamen Park  ;  Seong-lan Yu  ;  Sungju Jee  ;  Keun-Ah Cheon  ;  Dong Ho Song  ;  Seung Jun Kim  ;  Woo-Young Im  ;  Jaeku Kang 
Citation
 INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, Vol.53 : 83-89, 2016 
Journal Title
 INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE 
ISSN
 0736-5748 
Issue Date
2016
MeSH
Animals ; Animals, Newborn ; Attention Deficit Disorder with Hyperactivity/therapy* ; Brain-Derived Neurotrophic Factor/metabolism ; Central Nervous System Stimulants/adverse effects ; Chromatography, High Pressure Liquid ; Exploratory Behavior/drug effects ; Male ; Maze Learning/drug effects ; Methylphenidate/adverse effects ; Neurotransmitter Agents/metabolism ; Rats ; Rats, Inbred SHR ; Rats, Inbred WKY ; Time Factors ; Transcranial Magnetic Stimulation/methods*
Keywords
Attention-deficit hyperactivity disorder (ADHD) ; Behavior analysis ; Brain-derived neurotrophic factor (BDNF) ; Catecholamines ; Repetitive transcranial magnetic stimulation (rTMS) ; Spontaneously hypertensive rat (SHR)
Abstract
The current treatment of choice for attention deficit hyperactivity disorder (ADHD) is pharmacotherapy. A search for new treatment options is underway, however, as the wide application of drugs to the general population of patients with ADHD is limited by side effects and the variance of pharmacokinetic effects of the drugs in each patient. In the present study, we applied repetitive transcranial magnetic stimulation (rTMS), a non-invasive treatment used in a number of other psychiatric disorders, to spontaneously hypertensive rats (SHRs), an animal model of ADHD, in order to assess the efficacy of the treatment in modifying behavioural symptoms as well as levels of dopamine, noradrenaline, serotonin, and brain-derived neurotrophic factor (BDNF). A total of fifteen sessions of high-frequency rTMS treatment were administered. Behavioural symptoms were observed using open field, Y-maze, and elevated plus-maze tests. Upon completion of the experiments, rats were sacrificed, and the neurochemical changes in brain tissue were analysed using high performance liquid chromatography and Western blotting. The SHRs treated with rTMS tended to exhibit less locomotor activity in the open field test over the course of treatment, but there was no improvement in inattention as measured by the Y-maze test. Furthermore, BDNF concentration increased and noradrenaline concentration decreased in the prefrontal cortex of SHRs treated with rTMS. The results of the present preclinical study indicate that rTMS may constitute a new modality of treatment for patients with ADHD, through further evaluation of specific treatment parameters as well as safety and efficacy in humans are required.
Full Text
http://www.sciencedirect.com/science/article/pii/S0736574816301721?via%3Dihub
DOI
10.1016/j.ijdevneu.2016.07.006
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Song, Dong Ho(송동호) ORCID logo https://orcid.org/0000-0002-9647-3130
Cheon, Keun Ah(천근아) ORCID logo https://orcid.org/0000-0001-7113-9286
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152160
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