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Effects of microsatellite instability on recurrence patterns and outcomes in colorectal cancers

Authors
 Chang Gon Kim  ;  Joong Bae Ahn  ;  Minkyu Jung  ;  Seung Hoon Beom  ;  Chan Kim  ;  Joo Hoon Kim  ;  Su Jin Heo  ;  Hyung Soon Park  ;  Jee Hung Kim  ;  Nam Kyu Kim  ;  Byung Soh Min  ;  Hoguen Kim  ;  Woong Sub Koom  ;  Sang Joon Shin 
Citation
 BRITISH JOURNAL OF CANCER, Vol.115(1) : 25-33, 2016 
Journal Title
 BRITISH JOURNAL OF CANCER 
ISSN
 0007-0920 
Issue Date
2016
MeSH
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Colorectal Neoplasms/genetics* ; Colorectal Neoplasms/pathology* ; Disease-Free Survival ; Female ; Humans ; Male ; Microsatellite Instability ; Microsatellite Repeats/genetics* ; Middle Aged ; Neoplasm Recurrence, Local/genetics* ; Neoplasm Recurrence, Local/pathology* ; Prognosis ; Proportional Hazards Models ; Young Adult
Keywords
colorectal cancer ; colon cancer ; microsatellite instability ; recurrence pattern ; disease-free survival ; overall survival
Abstract
BACKGROUND: Among colorectal cancers (CRCs), high-frequency microsatellite instability (MSI-H) is associated with a better prognosis, compared with low-frequency MSI or microsatellite stability (MSI-L/MSS). However, it is unclear whether MSI affects the prognosis of recurrent CRCs. METHODS: This study included 2940 patients with stage I-III CRC who underwent complete resection. The associations of MSI status with recurrence patterns, disease-free survival (DFS), overall survival from diagnosis to death (OS1), and overall survival from recurrence to death (OS2) were analysed. RESULTS: A total of 261 patients (8.9%) had MSI-H CRC. Patients with MSI-H CRC had better DFS, compared to patients with MSI-L/MSS CRC (hazard ratio (HR): 0.619, P<0.001). High-frequency microsatellite instability CRC was associated with more frequent local recurrence (30.0% vs 12.0%, P=0.032) or peritoneal metastasis (40.0% vs 12.3%, P=0.003), and less frequent lung (10.0% vs 42.5%, P=0.004) or liver metastases (15.0% vs 44.7%, P=0.01). Recurrent MSI-H CRC was associated with worse OS1 (HR: 1.363, P=0.035) and OS2 (HR: 2.667, P<0.001). An analysis of patients with colon cancer yielded similar results. CONCLUSIONS: Recurrence patterns differed between MSI-H CRC and MSI-L/MSS CRC, and recurrent MSI-H CRCs had a worse prognosis.
Full Text
http://www.nature.com/bjc/journal/v115/n1/full/bjc2016161a.html
DOI
10.1038/bjc.2016.161
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Koom, Woong Sub(금웅섭) ORCID logo https://orcid.org/0000-0002-9435-7750
Kim, Nam Kyu(김남규) ORCID logo https://orcid.org/0000-0003-0639-5632
Kim, Joo Hoon(김주훈)
Kim, Jee Hung(김지형) ORCID logo https://orcid.org/0000-0002-9044-8540
Kim, Ho Keun(김호근)
Min, Byung Soh(민병소) ORCID logo https://orcid.org/0000-0003-0180-8565
Park, Hyung Soon(박형순)
Beom, Seung Hoon(범승훈) ORCID logo https://orcid.org/0000-0001-7036-3753
Shin, Sang Joon(신상준) ORCID logo https://orcid.org/0000-0001-5350-7241
Ahn, Joong Bae(안중배) ORCID logo https://orcid.org/0000-0001-6787-1503
Jung, Min Kyu(정민규) ORCID logo https://orcid.org/0000-0001-8281-3387
Heo, Su Jin(허수진) ORCID logo https://orcid.org/0000-0002-0615-5869
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152150
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