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Effects of microsatellite instability on recurrence patterns and outcomes in colorectal cancers

 Chang Gon Kim  ;  Joong Bae Ahn  ;  Minkyu Jung  ;  Seung Hoon Beom  ;  Chan Kim  ;  Joo Hoon Kim  ;  Su Jin Heo  ;  Hyung Soon Park  ;  Jee Hung Kim  ;  Nam Kyu Kim  ;  Byung Soh Min  ;  Hoguen Kim  ;  Woong Sub Koom  ;  Sang Joon Shin 
 British Journal of Cancer, Vol.115(1) : 25-33, 2016 
Journal Title
 British Journal of Cancer 
Issue Date
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Colorectal Neoplasms/genetics* ; Colorectal Neoplasms/pathology* ; Disease-Free Survival ; Female ; Humans ; Male ; Microsatellite Instability ; Microsatellite Repeats/genetics* ; Middle Aged ; Neoplasm Recurrence, Local/genetics* ; Neoplasm Recurrence, Local/pathology* ; Prognosis ; Proportional Hazards Models ; Young Adult
colorectal cancer ; colon cancer ; microsatellite instability ; recurrence pattern ; disease-free survival ; overall survival
BACKGROUND: Among colorectal cancers (CRCs), high-frequency microsatellite instability (MSI-H) is associated with a better prognosis, compared with low-frequency MSI or microsatellite stability (MSI-L/MSS). However, it is unclear whether MSI affects the prognosis of recurrent CRCs. METHODS: This study included 2940 patients with stage I-III CRC who underwent complete resection. The associations of MSI status with recurrence patterns, disease-free survival (DFS), overall survival from diagnosis to death (OS1), and overall survival from recurrence to death (OS2) were analysed. RESULTS: A total of 261 patients (8.9%) had MSI-H CRC. Patients with MSI-H CRC had better DFS, compared to patients with MSI-L/MSS CRC (hazard ratio (HR): 0.619, P<0.001). High-frequency microsatellite instability CRC was associated with more frequent local recurrence (30.0% vs 12.0%, P=0.032) or peritoneal metastasis (40.0% vs 12.3%, P=0.003), and less frequent lung (10.0% vs 42.5%, P=0.004) or liver metastases (15.0% vs 44.7%, P=0.01). Recurrent MSI-H CRC was associated with worse OS1 (HR: 1.363, P=0.035) and OS2 (HR: 2.667, P<0.001). An analysis of patients with colon cancer yielded similar results. CONCLUSIONS: Recurrence patterns differed between MSI-H CRC and MSI-L/MSS CRC, and recurrent MSI-H CRCs had a worse prognosis.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실)
Yonsei Authors
금웅섭(Koom, Woong Sub) ORCID logo https://orcid.org/0000-0002-9435-7750
김남규(Kim, Nam Kyu) ORCID logo https://orcid.org/0000-0003-0639-5632
김주훈(Kim, Joo Hoon)
김지형(Kim, Jee Hung) ORCID logo https://orcid.org/0000-0002-9044-8540
김호근(Kim, Ho Keun)
민병소(Min, Byung Soh)
박형순(Park, Hyung Soon)
범승훈(Beom, Seung Hoon) ORCID logo https://orcid.org/0000-0001-7036-3753
신상준(Shin, Sang Joon) ORCID logo https://orcid.org/0000-0001-5350-7241
안중배(Ahn, Joong Bae) ORCID logo https://orcid.org/0000-0001-6787-1503
정민규(Jung, Min Kyu) ORCID logo https://orcid.org/0000-0001-8281-3387
허수진(Heo, Su Jin) ORCID logo https://orcid.org/0000-0002-0615-5869
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