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Associations between elevated resting heart rate and subclinical atherosclerosis in asymptomatic Korean adults undergoing coronary artery calcium scoring

Authors
 Donghee Han  ;  Ji Hyun Lee  ;  Asim Rizvi  ;  Lohendran Baskaran  ;  Hyo Eun Park  ;  Su-Yeon Choi  ;  Eun Ju Chun  ;  Jidong Sung  ;  Sung Hak Park  ;  Hae-Won Han  ;  James K. Min  ;  Hyuk-Jae Chang  ;  Br?ain ? Hartaigh 
Citation
 INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING, Vol.32(10) : 1587-1593, 2016 
Journal Title
 INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING 
ISSN
 1569-5794 
Issue Date
2016
MeSH
Asymptomatic Diseases ; Chi-Square Distribution ; Coronary Angiography/methods* ; Coronary Artery Disease/diagnostic imaging* ; Coronary Artery Disease/physiopathology ; Coronary Vessels/diagnostic imaging* ; Female ; Heart Rate* ; Humans ; Linear Models ; Logistic Models ; Male ; Middle Aged ; Multidetector Computed Tomography* ; Multivariate Analysis ; Odds Ratio ; Predictive Value of Tests ; Registries ; Republic of Korea ; Retrospective Studies ; Risk Factors ; Severity of Illness Index ; Vascular Calcification/diagnostic imaging* ; Vascular Calcification/physiopathology
Keywords
Atherosclerosis ; Coronary artery calcium ; Korean adults ; Resting heart rate
Abstract
Elevated resting heart rate (RHR) and the presence of coronary artery calcium (CAC) are closely related with inflammatory activity and cardiovascular disease outcomes. To date, however, the relationship between a high RHR and CAC has not been well studied, especially in non-western populations. We therefore aimed to examine the cross-sectional relationship between high RHR and the burden of subclinical atherosclerosis as measured by CAC score in a large sample of Korean adults. A total 26,018 subjects were enrolled and underwent CAC screening as part of a broader general health examination. RHR was categorized into four groups as: <60, 60-69, 70-79, and ≥80 beats per minute. Multivariable logistic regression models were employed to estimate the odds of having a CAC score of either >0, >100, or >400 based on RHR. Mean age of the study population was 53.9?±?8.2 years, and 79.7?% were male. After adjustment, each 10 beat per minute increment in RHR was associated with greater odds of having a CAC score above 100 (OR 1.13, 95?% CI 1.08-1.18) or 400 (OR 1.22, 95?% CI 1.13-1.31). Likewise, following adjustment, the odds of having a CAC >100 or >400 for those with a RHR ≥80 beats per minute were 1.42 (95?% CI 1.19-1.69) and 1.86 (95?% CI 1.42-2.47), respectively, compared with those who had a RHR <60 beats per minute. In a large cohort of Korean adults, elevations in the RHR, particularly above 80 beats per minute, were found to be independently associated with the presence of subclinical atherosclerosis as measured by CAC scoring.
Full Text
https://link.springer.com/article/10.1007%2Fs10554-016-0944-7
DOI
10.1007/s10554-016-0944-7
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Jee Hyun(이지현)
Chang, Hyuk-Jae(장혁재) ORCID logo https://orcid.org/0000-0002-6139-7545
Han, Donghee(한동희)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152115
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