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Resting heart rate as a prognostic factor for mortality in patients with breast cancer

Authors
 Dong Hoon Lee  ;  Seho Park  ;  Sung Mook Lim  ;  Mi Kyung Lee  ;  Edward L. Giovannucci  ;  Joo Heung Kim  ;  Seung Il Kim  ;  Justin Y. Jeon 
Citation
 BREAST CANCER RESEARCH AND TREATMENT, Vol.159(2) : 375-384, 2016 
Journal Title
 BREAST CANCER RESEARCH AND TREATMENT 
ISSN
 0167-6806 
Issue Date
2016
MeSH
Adult ; Breast Neoplasms/mortality* ; Breast Neoplasms/pathology ; Female ; Heart/physiopathology* ; Heart Rate ; Humans ; Middle Aged ; Neoplasm Staging ; Prognosis ; Republic of Korea ; Retrospective Studies
Keywords
Breast cancer ; Prognosis ; Resting heart rate ; Survival
Abstract
Although elevated resting heart rate (RHR) has been shown to be associated with mortality in the general population and patients with certain diseases, no study has examined this association in patients with breast cancer. A total of 4786 patients with stage I-III breast cancer were retrospectively selected from the Severance hospital breast cancer registry in Seoul, Korea. RHR was measured at baseline and the mean follow-up time for all patients was 5.0 ± 2.5 years. Hazard ratios (HRs) with 95 % confidence intervals (CIs) were calculated using Cox regression models. After adjustment for prognostic factors, patients in the highest quintile of RHR (≥85 beat per minute (bpm)) had a significantly higher risk of all-cause mortality (HR: 1.57; 95 %CI 1.05-2.35), breast cancer-specific mortality (HR: 1.69; 95 %CI 1.07-2.68), and cancer recurrence (HR: 1.49; 95 %CI 0.99-2.25), compared to those in the lowest quintile (≤67 bpm). Moreover, every 10 bpm increase in RHR was associated with 15, 22, and 6 % increased risk of all-cause mortality, breast cancer-specific mortality, and cancer recurrence, respectively. However, the association between RHR and cancer recurrence was not statistically significant (p = 0.26). Elevated RHR was associated with an increased risk of mortality in patients with breast cancer. The findings from this study suggest that RHR may be used as a prognostic factor for patients with breast cancer in clinical settings.
Full Text
https://link.springer.com/article/10.1007%2Fs10549-016-3938-1
DOI
10.1007/s10549-016-3938-1
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Seung Il(김승일)
Kim, Joo Heung(김주흥) ORCID logo https://orcid.org/0000-0002-0417-8434
Park, Se Ho(박세호) ORCID logo https://orcid.org/0000-0001-8089-2755
Lim, Sung Mook(임성묵)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152104
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