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Cranofacial osteosarcoma: Single institutional experience in Korea

Authors
 Seungtaek Lim  ;  Soohyeon Lee  ;  Sun Young Rha  ;  Jae Kyung Rho 
Citation
 ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, Vol.12(1) : 149-153, 2016 
Journal Title
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
ISSN
 1743-7555 
Issue Date
2016
MeSH
Adult ; Aged ; Bone Neoplasms/mortality ; Bone Neoplasms/pathology* ; Bone Neoplasms/surgery ; Disease-Free Survival ; Facial Bones/pathology ; Female ; Head and Neck Neoplasms/mortality ; Head and Neck Neoplasms/pathology* ; Head and Neck Neoplasms/surgery ; Humans ; Male ; Middle Aged ; Neoplasm Recurrence, Local/pathology ; Osteosarcoma/mortality ; Osteosarcoma/pathology* ; Osteosarcoma/surgery ; Republic of Korea ; Retrospective Studies ; Skull/pathology ; Young Adult
Keywords
head and neck neoplasm ; metastasectomy ; prognosis ; recurrence ; sarcoma
Abstract
INTRODUCTION: Craniofacial osteosarcoma is a rare disease accounting for only 1% of all head and neck malignancies. Its clinical features and optimal treatments are not yet clearly established.

METHODS: We retrospectively analyzed the clinical course of 15 patients with craniofacial osteosarcoma treated in a single institute.

RESULTS: Out of 13 patients who initially underwent primary mass resection, disease recurrence was found in five (36%). Patients with positive surgical margins showed higher recurrence and shorter median recurrence-free and overall survival. Of three patients who had secondary operation after local recurrence, two survived for 44.6 and 64.2 months, respectively. One patient who underwent repeated lung metastasectomy had a disease-free survival of 18.4 months from the first recurrence.

CONCLUSION: The current study demonstrates that positive surgical margins are important predictive factors for recurrence and overall survival. Salvage surgery for local recurrence and metastasectomy for systemic recurrence might have a positive impact on survival.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/ajco.12072/abstract
DOI
10.1111/ajco.12072
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Rha, Sun Young(라선영) ORCID logo https://orcid.org/0000-0002-2512-4531
Lim, Seung Taek(임승택)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152083
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