Adult ; Aged ; Bone Neoplasms/mortality ; Bone Neoplasms/pathology* ; Bone Neoplasms/surgery ; Disease-Free Survival ; Facial Bones/pathology ; Female ; Head and Neck Neoplasms/mortality ; Head and Neck Neoplasms/pathology* ; Head and Neck Neoplasms/surgery ; Humans ; Male ; Middle Aged ; Neoplasm Recurrence, Local/pathology ; Osteosarcoma/mortality ; Osteosarcoma/pathology* ; Osteosarcoma/surgery ; Republic of Korea ; Retrospective Studies ; Skull/pathology ; Young Adult
Keywords
head and neck neoplasm ; metastasectomy ; prognosis ; recurrence ; sarcoma
Abstract
INTRODUCTION: Craniofacial osteosarcoma is a rare disease accounting for only 1% of all head and neck malignancies. Its clinical features and optimal treatments are not yet clearly established.
METHODS: We retrospectively analyzed the clinical course of 15 patients with craniofacial osteosarcoma treated in a single institute.
RESULTS: Out of 13 patients who initially underwent primary mass resection, disease recurrence was found in five (36%). Patients with positive surgical margins showed higher recurrence and shorter median recurrence-free and overall survival. Of three patients who had secondary operation after local recurrence, two survived for 44.6 and 64.2 months, respectively. One patient who underwent repeated lung metastasectomy had a disease-free survival of 18.4 months from the first recurrence.
CONCLUSION: The current study demonstrates that positive surgical margins are important predictive factors for recurrence and overall survival. Salvage surgery for local recurrence and metastasectomy for systemic recurrence might have a positive impact on survival.