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Clinical Significance of CA125 Level after the First Cycle of Chemotherapy on Survival of Patients with Advanced Ovarian Cancer

Authors
 Maria Lee  ;  Min Young Chang  ;  Hanna Yoo  ;  Kyung Eun Lee  ;  Doo Byung Chay  ;  Hanbyoul Cho  ;  Sunghoon Kim  ;  Young Tae Kim  ;  Jae-Hoon Kim 
Citation
 YONSEI MEDICAL JOURNAL, Vol.57(3) : 580-587, 2016 
Journal Title
 YONSEI MEDICAL JOURNAL 
ISSN
 0513-5796 
Issue Date
2016
MeSH
Adult ; Aged ; Aged, 80 and over ; Antineoplastic Agents/therapeutic use* ; CA-125 Antigen/blood* ; CA-125 Antigen/metabolism ; Disease-Free Survival ; Female ; Humans ; Middle Aged ; Neoplasm Staging ; Neoplasms, Glandular and Epithelial/blood* ; Neoplasms, Glandular and Epithelial/drug therapy* ; Neoplasms, Glandular and Epithelial/mortality ; Ovarian Neoplasms/blood* ; Ovarian Neoplasms/drug therapy* ; Ovarian Neoplasms/mortality ; Prognosis ; Regression Analysis
Keywords
CA125 ; ovarian cancer ; prognostic factor ; tumour marker
Abstract
PURPOSE: To determine the most powerful cancer antigen 125 (CA125)-related prognostic factor for advanced epithelial ovarian cancer (EOC) and to identify cut-off values that distinguish patients with a poor prognosis from those with a good prognosis. MATERIALS AND METHODS: We included 223 patients who received staging laparotomy and were diagnosed with stage IIC-IV serous EOC. Cox regression analysis was used to determine the most significant prognostic factor among the following variables: serum CA125 before surgery and after the first, second, and sixth cycles of chemotherapy; the nadir CA125 value; the relative percentage change in CA125 levels after the first and second cycles of chemotherapy compared to baseline CA125; CA125 half-life; time to nadir; and time to normalization of the CA125 level. RESULTS: The CA125 level after the first chemotherapy cycle was the most significant independent prognostic factor for overall survival (OS). Time to normalization (p=0.028) and relative percentage change between CA125 levels at baseline and after the first chemotherapy cycle (p=0.021) were additional independent prognostic factors in terms of OS. The CA125 level after the first chemotherapy cycle (p=0.001) and time to normalization (p<0.001) were identified as independent prognostic factors for progression free survival (PFS). CONCLUSION: Among well-established CA125-related prognostic factors, serum CA125 levels after the first cycle of chemotherapy and time to normalization were the most significant prognostic factors for both OS and PFS.
Files in This Item:
T201603569.pdf Download
DOI
10.3349/ymj.2016.57.3.580
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sung Hoon(김성훈) ORCID logo https://orcid.org/0000-0002-1645-7473
Kim, Young Tae(김영태) ORCID logo https://orcid.org/0000-0002-7347-1052
Kim, Jae Hoon(김재훈) ORCID logo https://orcid.org/0000-0001-6599-7065
Chang, Min Young(장민영)
Cho, Hanbyoul(조한별) ORCID logo https://orcid.org/0000-0002-6177-1648
Chay, Doo Byung(채두병) ORCID logo https://orcid.org/0000-0002-0648-4021
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152048
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