140 331

Cited 8 times in

Is lymphovascular invasion a powerful predictor for biochemical recurrence in pT3 N0 prostate cancer? Results from the K-CaP database

 Yong Hyun Park  ;  Yejin Kim  ;  Hwanjo Yu  ;  In Young Choi  ;  Seok-Soo Byun  ;  Cheol Kwak  ;  Byung Ha Chung  ;  Hyun Moo Lee  ;  Choung Soo Kim  ;  Ji Youl Lee 
 SCIENTIFIC REPORTS, Vol.6 : 25419, 2016 
Journal Title
Issue Date
Aged ; Bayes Theorem ; Humans ; Lymphatic Metastasis ; Male ; Middle Aged ; Neoplasm Invasiveness ; Neoplasm Recurrence, Local/metabolism ; Neoplasm Recurrence, Local/pathology* ; Neoplasm Staging ; Prognosis ; Prostate-Specific Antigen/metabolism* ; Prostatic Neoplasms/metabolism ; Prostatic Neoplasms/pathology* ; Survival Analysis ; Vascular Neoplasms/metabolism ; Vascular Neoplasms/secondary*
To assess the impact of lymphovascular invasion (LVI) on the risk of biochemical recurrence (BCR) in pT3 N0 prostate cancer, clinical data were extracted from 1,622 patients with pT3 N0 prostate cancer from the K-CaP database. Patients with neoadjuvant androgen deprivation therapy (n?=?325) or insufficient pathologic or follow-up data (n?=?87) were excluded. The primary endpoint was the oncologic importance of LVI, and the secondary endpoint was the hierarchical relationships for estimating BCR between the evaluated variables. LVI was noted in 260 patients (21.5%) and was significantly associated with other adverse clinicopathologic features. In the multivariate Cox regression analysis, LVI was significantly associated with an increased risk of BCR after adjusting for known prognostic factors. In the Bayesian belief network analysis, LVI and pathologic Gleason score were found to be first-degree associates of BCR, whereas prostate-specific antigen (PSA) level, seminal vesicle invasion, perineural invasion, and high-grade prostatic intraepithelial neoplasia were considered second-degree associates. In the random survival forest, pathologic Gleason score, LVI, and PSA level were three most important variables in determining BCR of patients with pT3 N0 prostate cancer. In conclusion, LVI is one of the most powerful adverse prognostic factors for BCR in patients with pT3 N0 prostate cancer.
Files in This Item:
T201603633.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Chung, Byung Ha(정병하) ORCID logo https://orcid.org/0000-0001-9817-3660
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.