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Sarcopenia is associated with albuminuria independently of hypertension and diabetes: KNHANES 2008-2011

Authors
 Eugene Han  ;  Yong-ho Lee  ;  Gyuri Kim  ;  So Ra Kim  ;  Byung-Wan Lee  ;  Eun Seok Kang  ;  Chul Woo Ahn  ;  Bong-Soo Cha 
Citation
 METABOLISM-CLINICAL AND EXPERIMENTAL, Vol.65(10) : 1531-1540, 2016 
Journal Title
METABOLISM-CLINICAL AND EXPERIMENTAL
ISSN
 0026-0495 
Issue Date
2016
MeSH
Absorptiometry, Photon ; Adult ; Aged ; Aged, 80 and over ; Aging/metabolism ; Albuminuria/complications* ; Albuminuria/epidemiology ; Body Mass Index ; Cross-Sectional Studies ; Diabetes Mellitus/epidemiology* ; Female ; Humans ; Hypertension/complications* ; Hypertension/epidemiology ; Insulin Resistance ; Male ; Middle Aged ; Muscle, Skeletal/metabolism ; Nutrition Surveys ; Obesity/complications ; Obesity/epidemiology ; Republic of Korea/epidemiology ; Sarcopenia/epidemiology ; Sarcopenia/etiology* ; Young Adult
Keywords
Albuminuria ; Diabetes ; Hypertension ; Obesity ; Sarcopenia
Abstract
INTRODUCTION: Although sarcopenia is associated with metabolic disorders, its influence on albuminuria has not been determined. The aim of this study was to identify the relationship between sarcopenia and albuminuria in the general population.

METHODS: This was a population-based, cross-sectional study using a nationally representative sample of 2326 subjects aged ≥20years from the Korea National Health and Nutrition Examination Surveys of 2008-2011. Appendicular skeletal muscle (ASM) measured by dual-energy X-ray absorptiometry was used to assess sarcopenia, which was defined as ASM divided by body mass index, as recommended by the international consensus meeting of the National Institutes of Health. Albuminuria was defined as an albumin-to-creatinine ratio of ≥30mg/g using random spot urine samples.

RESULTS: A total of 385 (16.5%) subjects were classified as having albuminuria. Sarcopenic subjects showed a higher proportion of albuminuria than subjects without sarcopenia (odds ratios [ORs]=2.17-3.26, all P<0.05) after stratification based on the presence of hypertension, diabetes, or metabolic syndrome and a higher homeostasis model assessment of insulin resistance (all P<0.001). The albuminuria risk was comparable between insulin-sensitive subjects with sarcopenia and insulin-resistant subjects with preserved muscle mass. A multiple logistic regression analysis also demonstrated that sarcopenia was independently associated with albuminuria (OR=1.61, 95% confidence interval [CI]=1.04-2.48, P<0.05). The association between sarcopenia and albuminuria remained strong in the elderly population (ORs=1.80-2.68, P<0.05), whereas it lost its significance in the younger age group. Furthermore, the risk of albuminuria was much higher in sarcopenic obese subjects than in other groups (OR=4.90, 95% CI=3.23-7.43, P<0.001).

CONCLUSIONS: Sarcopenia was associated with an increased risk of albuminuria independent of hypertension, diabetes, and metabolic syndrome. Sarcopenia and obesity had a synergistic impact on the increased risk of albuminuria. This suggests that sarcopenic obesity as well as sarcopenia alone may be considered as novel risk factors for albuminuria.
Full Text
http://www.sciencedirect.com/science/article/pii/S0026049516300671?via%3Dihub
DOI
10.1016/j.metabol.2016.07.003
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Hospital Medicine (입원의학과) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Eun Seok(강은석) ORCID logo https://orcid.org/0000-0002-0364-4675
Kim, Gyuri(김규리)
Kim, So Ra(김소라)
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Lee, Byung Wan(이병완) ORCID logo https://orcid.org/0000-0002-9899-4992
Lee, Yong Ho(이용호) ORCID logo https://orcid.org/0000-0002-6219-4942
Cha, Bong Soo(차봉수) ORCID logo https://orcid.org/0000-0003-0542-2854
Han, Eu Gene(한유진)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152010
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