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Vitamin D levels in allergic rhinitis: a systematic review and meta-analysis

 Yoon Hee Kim  ;  Kyung Won Kim  ;  Min Jung Kim  ;  In Suk Sol  ;  Seo Hee Yoon  ;  Hyeong Sik Ahn  ;  Hyun Jung Kim  ;  Myung Hyun Sohn  ;  Kyu-Earn Kim 
 Pediatric Allergy and Immunology, Vol.27(6) : 580-590, 2016 
Journal Title
 Pediatric Allergy and Immunology 
Issue Date
Adult ; Animals ; Asthma/epidemiology* ; Child ; Humans ; Incidence ; Prevalence ; Rhinitis, Allergic/epidemiology* ; Vitamin D/metabolism* ; Vitamin D Deficiency/epidemiology*
allergic rhinitis ; children ; incidence ; prevalence ; vitamin D
BACKGROUND: We aimed to systematically review observational studies investigating the relationship between vitamin D levels and allergic rhinitis (AR). METHODS: Studies were selected if they evaluated the relationship between vitamin D levels and AR, and included studies that evaluated other allergic conditions if those studies also contained data on AR. We assessed the incidence and prevalence of AR according to vitamin D levels and compared vitamin D levels in patients with AR to levels in controls. RESULTS: Nineteen studies were selected. Of these, only seven focused solely on AR; 10 studies evaluated the other allergic diseases as well as AR; and two studies evaluated asthma primarily, but also included data on patients with AR. The pooled odds ratios (ORs) for the incidence of AR according to vitamin D levels were not statistically significant for either children or adults. Lower vitamin D levels were associated with a higher AR prevalence only in children (pooled OR [95% confidence interval (CI)], 0.75 [0.58, 0.98]). The pooled mean vitamin D level in patients with AR was lower than that of controls only in children (pooled means difference [95% CI], -7.63 [-13.08, -2.18]). CONCLUSIONS: Prior vitamin D levels were not related to developing AR, but lower vitamin D levels were associated with a higher AR prevalence only in children. There is insufficient evidence to support vitamin D supplementation for AR prevention. However, physicians should consider evaluating patients for vitamin D deficiency during AR management, especially in children.
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1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Won(김경원) ORCID logo https://orcid.org/0000-0003-4529-6135
Kim, Kyu Earn(김규언)
Kim, Min Jung(김민정) ORCID logo https://orcid.org/0000-0002-5634-9709
Kim, Yoon Hee(김윤희) ORCID logo https://orcid.org/0000-0002-2149-8501
Sol, In Suk(설인숙) ORCID logo https://orcid.org/0000-0003-2470-9682
Sohn, Myung Hyun(손명현) ORCID logo https://orcid.org/0000-0002-2478-487X
Yoon, Seo Hee(윤서희) ORCID logo https://orcid.org/0000-0002-8361-9815
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