90 98

Cited 14 times in

Usefulness of neutrophil-lymphocyte ratio in young children with febrile urinary tract infection

Authors
 Song Yi Han  ;  I Re Lee  ;  Se Jin Park  ;  Ji Hong Kim  ;  Jae Il Shin 
Citation
 Korean Journal of Pediatrics, Vol.59(3) : 139-144, 2016 
Journal Title
 Korean Journal of Pediatrics 
ISSN
 1738-1061 
Issue Date
2016
Keywords
Child ; Neutrophil-lymphocyte ratio ; Pyelonephritis ; Urinary tract infections ; Vesico-ureteral reflux
Abstract
Purpose : Acute pyelonephritis (APN) is a serious bacterial infection that can cause renal scarring in children. Early identification of APN is critical to improve treatment outcomes. The neutrophil-lymphocyte ratio (NLR) is a prognostic marker of many diseases, but it has not yet been established in urinary tract infection (UTI). The aim of this study was to determine whether NLR is a useful marker to predict APN or vesicoureteral reflux (VUR). Methods : We retrospectively evaluated 298 pediatric patients (age≤36 months) with febrile UTI from January 2010 to December 2014. Conventional infection markers (white blood cell [WBC] count, erythrocyte sedimentation rate [ESR], C-reactive protein [CRP]), and NLR were measured. Results : WBC, CRP, ESR, and NLR were higher in APN than in lower UTI (P<0.001). Multiple logistic regression analyses showed that NLR was a predictive factor for positive dimercaptosuccinic acid (DMSA) defects (P<0.001). The area under the receiver operating characteristic (ROC) curve was high for NLR (P<0.001) as well as CRP (P<0.001) for prediction of DMSA defects. NLR showed the highest area under the ROC curve for diagnosis of VUR (P<0.001). Conclusion : NLR can be used as a diagnostic marker of APN with DMSA defect, showing better results than those of conventional markers for VUR prediction.
Files in This Item:
T201603533.pdf Download
DOI
10.3345/kjp.2016.59.3.139
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Ji Hong(김지홍) ORCID logo https://orcid.org/0000-0001-5352-5423
Shin, Jae Il(신재일) ORCID logo https://orcid.org/0000-0003-2326-1820
Lee, I Re(이이레)
Han, Song Yi(한송이)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/151988
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse