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Aggressive surgical resection for concomitant liver and lung metastasis in colorectal cancer

 Sung Hwan Lee  ;  Sung Hyun Kim  ;  Jin Hong Lim  ;  Sung Hoon Kim  ;  Jin Gu Lee  ;  Dae Joon Kim  ;  Gi Hong Choi  ;  Jin Sub Choi  ;  Kyung Sik Kim 
 Korean Journal of Hepato-Biliary-Pancreatic Surgery, Vol.20(3) : 110-115, 2016 
Journal Title
Korean Journal of Hepato-Biliary-Pancreatic Surgery(한국간담췌외과학회지)
Issue Date
Colorectal cancer ; Liver cancer ; Lung cancer ; Metastasis
Backgrounds/Aims : Aggressive surgical resection for hepatic metastasis is validated, however, concomitant liver and lung metastasis in colorectal cancer patients is equivocal.

Methods : Clinicopathologic data from January 2008 through December 2012 were retrospectively reviewed in 234 patients with colorectal cancer with concomitant liver and lung metastasis. Clinicopathologic factors and survival data were analyzed.

Results : Of the 234 patients, 129 (55.1%) had synchronous concomitant liver and lung metastasis from colorectal cancer and 36 (15.4%) had metachronous metastasis. Surgical resection was performed in 33 patients (25.6%) with synchronous and 6 (16.7%) with metachronous metastasis. Surgical resection showed better overall survival in both groups (synchronous, p=0.001; metachronous, p=0.028). In the synchronous metastatic group, complete resection of both liver and lung metastatic lesions had better survival outcomes than incomplete resection of two metastatic lesions (p=0.037). The primary site of colorectal cancer and complete resection were significant prognostic factors (p=0.06 and p=0.003, respectively).

Conclusions: Surgical resection for hepatic and pulmonary metastasis in colorectal cancer can improve complete remission and survival rate in resectable cases. Colorectal cancer with concomitant liver and lung metastasis is not a poor prognostic factor or a contraindication for surgical treatments, hence, an aggressive surgical approach may be recommended in well-selected resectable cases.
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1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Sik(김경식) ORCID logo https://orcid.org/0000-0001-9498-284X
Kim, Dae Joon(김대준)
Kim, Sung Hyun(김성현) ORCID logo https://orcid.org/0000-0001-7683-9687
Lee, Sung Hwan(이성환)
Lee, Jin Gu(이진구)
Lim, Jin Hong(임진홍)
Choi, Gi Hong(최기홍) ORCID logo https://orcid.org/0000-0002-1593-3773
Choi, Jin Sub(최진섭)
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