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Comparing the Effect of Nonactivated Platelet-Rich Plasma, Activated Platelet-Rich Plasma, and Bone Morphogenetic Protein-2 on Calvarial Bone Regeneration

DC FieldValueLanguage
dc.contributor.author나동균-
dc.contributor.author정복기-
dc.contributor.author노태석-
dc.contributor.author이원재-
dc.contributor.author유대현-
dc.contributor.author윤인식-
dc.date.accessioned2017-10-26T07:23:27Z-
dc.date.available2017-10-26T07:23:27Z-
dc.date.issued2016-
dc.identifier.issn1049-2275-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/151967-
dc.description.abstractAlthough platelet-rich plasma (PRP) is widely used to enhance bone graft survival, the effect of PRP itself on bone regeneration is unclear. Because activated PRP releases many growth factors in a bolus, there are controversies regarding the effect of activation of the PRP on bone regeneration. Thus, we studied the effect of activated versus nonactivated PRP on bone regeneration and compared the effect with that of recombinant human bone morphogenetic protein-2 (rhBMP-2) in a critical-sized cranial defect model. Forty New Zealand white rabbits were randomly divided into 4 groups. Defect sizing 15 × 15 mm(2) was created on the cranium of each rabbit, and then a collagen sponge soaked with normal saline, rhBMP-2, nonactivated PRP, or PRP activated with CaCl2 solution was immediately placed on the defect. After 16 weeks, using three-dimensional computed tomography and digital photography, the volume and new bone surface area were measured. The newly created bone was histologically analyzed. The experimental groups showed a significantly increased volume and surface area of new bone compared with the control group (P < 0.05), but no significant differences were found among the experimental groups. Histologic examination in the experimental groups showed newly created bone that had emerged in the center as well as the margin of the defect. Overall, these results indicate that PRP enhanced bony regeneration regardless of activation with an effect that was comparable to that of rhBMP-2. Thus, PRP has therapeutic effects on bone regeneration and may replace rhBMP-2, which is costly.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherLippincott Williams & Wilkins-
dc.relation.isPartOfJournal of Craniofacial Surgery-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHBone Morphogenetic Protein 2/administration & dosage*-
dc.subject.MESHBone Morphogenetic Protein 2/physiology*-
dc.subject.MESHBone Regeneration/drug effects-
dc.subject.MESHBone Regeneration/physiology*-
dc.subject.MESHBone Transplantation/methods*-
dc.subject.MESHCalcium Chloride/pharmacology-
dc.subject.MESHImaging, Three-Dimensional-
dc.subject.MESHMale-
dc.subject.MESHPlatelet Activation/drug effects-
dc.subject.MESHPlatelet Activation/physiology*-
dc.subject.MESHPlatelet-Rich Plasma/physiology*-
dc.subject.MESHRabbits-
dc.subject.MESHRecombinant Proteins/administration & dosage-
dc.subject.MESHSkull/diagnostic imaging-
dc.subject.MESHSkull/physiopathology*-
dc.subject.MESHSkull/surgery*-
dc.subject.MESHTomography, X-Ray Computed-
dc.subject.MESHTransforming Growth Factor beta/administration & dosage*-
dc.subject.MESHTransforming Growth Factor beta/physiology*-
dc.titleComparing the Effect of Nonactivated Platelet-Rich Plasma, Activated Platelet-Rich Plasma, and Bone Morphogenetic Protein-2 on Calvarial Bone Regeneration-
dc.typeArticle-
dc.publisher.locationUnited States-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Plastic Surgery & Reconstructive Surgery-
dc.contributor.googleauthorJeon, Yeo Reum-
dc.contributor.googleauthorJung, Bok Ki-
dc.contributor.googleauthorRoh, Tai Suk-
dc.contributor.googleauthorKang, Eun Hye-
dc.contributor.googleauthorLee, Won Jai-
dc.contributor.googleauthorRah, Dong Kyun-
dc.contributor.googleauthorLew, Dae Hyun-
dc.contributor.googleauthorYun, In Sik-
dc.identifier.doi10.1097/SCS.0000000000002349-
dc.contributor.localIdA04665-
dc.contributor.localIdA01297-
dc.contributor.localIdA03005-
dc.contributor.localIdA02459-
dc.contributor.localIdA02588-
dc.contributor.localIdA01229-
dc.relation.journalcodeJ01356-
dc.identifier.pmid26967070-
dc.identifier.urlhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00001665-201603000-00010&LSLINK=80&D=ovft-
dc.subject.keywordBone morphogenetic protein-
dc.subject.keywordbone regeneration-
dc.subject.keywordcranial defect-
dc.subject.keywordnonactivated platelet-rich plasma-
dc.subject.keywordplatelet-rich plasma-
dc.contributor.alternativeNameRah, Dong Kyun-
dc.contributor.alternativeNameJung, Bok Ki-
dc.contributor.alternativeNameRoh, Tai Suk-
dc.contributor.alternativeNameLee, Won Jai-
dc.contributor.alternativeNameLew, Dae Hyun-
dc.contributor.alternativeNameYun, In Sik-
dc.contributor.affiliatedAuthorJung, Bok Ki-
dc.contributor.affiliatedAuthorRoh, Tai Suk-
dc.contributor.affiliatedAuthorLee, Won Jai-
dc.contributor.affiliatedAuthorLew, Dae Hyun-
dc.contributor.affiliatedAuthorYun, In Sik-
dc.contributor.affiliatedAuthorRah, Dong Kyun-
dc.citation.volume27-
dc.citation.number2-
dc.citation.startPage317-
dc.citation.endPage321-
dc.identifier.bibliographicCitationJournal of Craniofacial Surgery, Vol.27(2) : 317-321, 2016-
dc.date.modified2017-10-24-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Plastic and Reconstructive Surgery (성형외과학교실) > 1. Journal Papers

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