Cited 9 times in
Suppression of MicroRNA let-7a Expression by Agmatine Regulates Neural Stem Cell Differentiation
DC Field | Value | Language |
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dc.contributor.author | 김종열 | - |
dc.contributor.author | 이종은 | - |
dc.date.accessioned | 2017-10-26T07:23:25Z | - |
dc.date.available | 2017-10-26T07:23:25Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/151966 | - |
dc.description.abstract | Purpose : Neural stem cells (NSCs) effectively reverse some severe central nervous system (CNS) disorders, due to their ability to differentiate into neurons. Agmatine, a biogenic amine, has cellular protective effects and contributes to cellular proliferation and differentiation in the CNS. Recent studies have elucidated the function of microRNA let-7a (let-7a) as a regulator of cell differentiation with roles in regulating genes associated with CNS neurogenesis. Materials and Methods : This study aimed to investigate whether agmatine modulates the expression of crucial regulators of NSC differentiation including DCX, TLX, c-Myc, and ERK by controlling let-7a expression. Results : Our data suggest that high levels of let-7a promoted the expression of TLX and c-Myc, as well as repressed DCX and ERK expression. In addition, agmatine attenuated expression of TLX and increased expression of ERK by negatively regulating let-7a. Conclusion : Our study therefore enhances the present understanding of the therapeutic potential of NSCs in CNS disorders. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Yonsei University | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Agmatine/pharmacology* | - |
dc.subject.MESH | Cell Differentiation/drug effects* | - |
dc.subject.MESH | Cell Proliferation | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | MicroRNAs/metabolism* | - |
dc.subject.MESH | Neural Stem Cells/cytology | - |
dc.subject.MESH | Neural Stem Cells/drug effects* | - |
dc.subject.MESH | Neurogenesis/drug effects* | - |
dc.subject.MESH | Neurons/cytology | - |
dc.subject.MESH | Neurons/drug effects | - |
dc.subject.MESH | Neurons/metabolism | - |
dc.title | Suppression of MicroRNA let-7a Expression by Agmatine Regulates Neural Stem Cell Differentiation | - |
dc.type | Article | - |
dc.publisher.location | Korea (South) | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Anatomy | - |
dc.contributor.googleauthor | Juhyun Song | - |
dc.contributor.googleauthor | Yumi Oh | - |
dc.contributor.googleauthor | Jong Youl Kim | - |
dc.contributor.googleauthor | Kyoung Joo Cho | - |
dc.contributor.googleauthor | Jong Eun Lee | - |
dc.identifier.doi | 10.3349/ymj.2016.57.6.1461 | - |
dc.contributor.localId | A03146 | - |
dc.contributor.localId | A00923 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 27593875 | - |
dc.subject.keyword | DCX | - |
dc.subject.keyword | ERK | - |
dc.subject.keyword | Neural stem cell (NSCs) | - |
dc.subject.keyword | TLX | - |
dc.subject.keyword | agmatine | - |
dc.subject.keyword | microRNA let-7a (let-7a) | - |
dc.contributor.alternativeName | Kim, Jong Youl | - |
dc.contributor.alternativeName | Lee, Jong Eun | - |
dc.contributor.affiliatedAuthor | Lee, Jong Eun | - |
dc.contributor.affiliatedAuthor | Kim, Jong Youl | - |
dc.citation.volume | 57 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1461 | - |
dc.citation.endPage | 1467 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.57(6) : 1461-1467, 2016 | - |
dc.date.modified | 2017-10-24 | - |
dc.identifier.rimsid | 46288 | - |
dc.type.rims | ART | - |
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