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Association between lipoprotein(a) and nonalcoholic fatty liver disease among Korean adults

Authors
 Ji Sun Nam  ;  Sehee Jo  ;  Shinae Kang  ;  ChulWoo Ahn  ;  Kyung Rae Kim  ;  Jong Suk Park 
Citation
 CLINICA CHIMICA ACTA, Vol.461 : 14-18, 2016 
Journal Title
 CLINICA CHIMICA ACTA 
ISSN
 0009-8981 
Issue Date
2016
MeSH
Cross-Sectional Studies ; Female ; Humans ; Lipoproteins/blood* ; Male ; Middle Aged ; Non-alcoholic Fatty Liver Disease/blood* ; Regression Analysis ; Republic of Korea ; Risk Factors
Keywords
Insulin resistance ; Lipoprotein(a) ; Nonalcoholic fatty liver disease
Abstract
BACKGROUND: Lipoprotein(a) [Lp(a)] and nonalcoholic fatty liver disease (NAFLD) are risk factors for cardiovascular diseases. We investigated the relationship between Lp(a) concentrations and NAFLD among Korean adults. METHODS: A total of 2242 nondiabetic subjects undergoing routine health screening examination were enrolled. Anthropometric and biochemical parameters, including Lp(a) were measured. NAFLD were assessed by ultrasonography. Adjusted Odds ratios for the presence of NAFLD according to Lp(a) tertiles were estimated using logistic regression. RESULTS: Subjects were grouped according to the severity of NAFLD and Lp(a) concentrations. Lp(a) concentrations were decreased across the severity of NAFLD and the prevalence of NAFLD decreased with the Lp(a) tertiles. Compared with subjects in the lowest tertile of Lp(a), those in the highest tertile had higher total cholesterol and LDL-C concentrations and lower body mass index, blood pressure, fasting glucose, triglyceride, ALT, and HOMA-IR concentrations. In the logistic regression analysis after adjusting for multiple risk factors, the relationship between Lp(a) concentrations and the presence of NAFLD remained significant. However, this association was attenuated after adjusting for insulin resistance. CONCLUSIONS: Lp(a) was inversely associated with the presence of NAFLD, but it was not an independent risk factor for NAFLD among Korean adults.
Full Text
http://www.sciencedirect.com/science/article/pii/S0009898116303023?via%3Dihub
DOI
10.1016/j.cca.2016.07.003
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Shin Ae(강신애) ORCID logo https://orcid.org/0000-0002-9719-4774
Kim, Kyung Rae(김경래)
Nam, Ji Sun(남지선) ORCID logo https://orcid.org/0000-0001-8655-5258
Park, Jong Suk(박종숙) ORCID logo https://orcid.org/0000-0002-5385-1373
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Jo, Se Hee(조세희)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/151888
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