Long-Term Recurrence Rates of Peptic Ulcers without Helicobacter pylori

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Authors: Jae Hyun Seo ; Su Jin Hong ; Jie-Hyun Kim ; Byung-Wook Kim ; Sam Ryong Jee ; Woo Chul Chung ; Ki-Nam Shim ; Gwang Ho Baik ; Sung Soo Kim ; Sang Gyun Kim ; Jin Il Kim

MeSH: Adult ; Age Factors ; Aged ; Anti-Bacterial Agents/therapeutic use ; Female ; Follow-Up Studies ; Helicobacter Infections*/complications ; Helicobacter Infections*/drug therapy ; Helicobacter Infections*/microbiology ; Helicobacter pylori* ; Humans ; Male ; Middle Aged ; Peptic Ulcer*/drug therapy ; Peptic Ulcer*/etiology ; Peptic Ulcer*/microbiology ; Recurrence ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/microbiology ; Republic of Korea ; Retrospective Studies ; Risk Factors ; Sex Factors ; Time Factors

Abstract: BACKGROUND/AIMS: The purpose of this study is to investigate the recurrence rate of peptic ulcer disease (PUD) over a long follow-up period with PUD patients without Helicobacter pylori.

METHODS: We retrospectively reviewed patients diagnosed with PUD on endoscopy and divided them into two groups: a H. pylori-negative group (HP-negative group), and a group of patients with untreated H. pylori (HP noneradicated group). We compared the recurrence rates of PUD in these two groups and analyzed the factors that affected ulcer recurrence.

RESULTS: Total of nine hospitals in Korea participated, and a total of 1,761 patients were retrospectively reviewed. The HP-negative group included 553 patients, and the HP noneradicated group included 372 patients. The 5-year cumulative probabilities of PUD recurrence were 36.4% in the HP-negative group and 43.8% in the HP noneradicated group (p=0.113). The factors that were found to affect recurrence in the HP-negative group were elder, male, and comorbid chronic kidney disease.

CONCLUSIONS: The 5-year cumulative probability of PUD recurrence without H. pylori infection after a long-term follow-up was 36.4% and the factors that affected recurrence were elder, male, and comorbid chronic kidney disease.