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De novo C3 glomerulonephritis in a renal allograft

Authors
 Ji Hae Nahm  ;  Seung Hwan Song  ;  Yu Seun Kim  ;  Hae-Il Cheong  ;  Beom Jin Lim  ;  Beom Seok Kim  ;  Hyeon Joo Jeong 
Citation
 Ultrastructural Pathology, Vol.40(2) : 112-115, 2016 
Journal Title
 Ultrastructural Pathology 
ISSN
 0191-3123 
Issue Date
2016
MeSH
Allografts ; Biopsy ; Complement C3/analysis* ; Disease Progression ; Fluorescent Antibody Technique ; Glomerulonephritis, Membranoproliferative/immunology* ; Glomerulonephritis, Membranoproliferative/pathology ; Humans ; Immunosuppressive Agents/therapeutic use ; Kidney Glomerulus/immunology* ; Kidney Glomerulus/ultrastructure ; Kidney Transplantation/adverse effects* ; Kidney Transplantation/methods ; Living Donors ; Male ; Microscopy, Electron ; Time Factors ; Treatment Outcome ; Young Adult
Keywords
C3 glomerulonephritis ; dense deposit disease ; kidney transplant ; rejection
Abstract
C3 glomerulonephritis (C3GN) is a recently described, rare glomerular disease characterized by predominant or sole glomerular C3 deposits. Morphologic features of C3GN are similar to those of dense deposit disease (DDD); however, ribbon-like intramembranous electron-dense deposits are absent in the former. We report a case of de novo C3GN in a renal allograft with morphologic transformation to DDD. A 6-year-old boy presented with congenital left renal agenesis and right ureteropelvic junction obstruction. The patient underwent pyeloplasty but experienced recurrent urinary tract infections. At the age of 22 years, he received a renal allograft from a living related donor. C3GN was diagnosed after 1 year of transplantation; initial histology showed minimal mesangiopathy and this progressed to mesangial proliferation and membranoproliferative features over the next 7 years. Serum creatinine levels were stabilized with anti-rejection treatments for combating repeated episodes of acute rejection; however, glomerular and tubular band-like electron-dense deposits became evident.
Full Text
http://www.tandfonline.com/doi/full/10.3109/01913123.2016.1154634
DOI
10.3109/01913123.2016.1154634
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
김범석(Kim, Beom Seok) ORCID logo https://orcid.org/0000-0002-5732-2583
김유선(Kim, Yu Seun) ORCID logo https://orcid.org/0000-0002-5105-1567
남지해(Nahm, Ji Hae) ORCID logo https://orcid.org/0000-0003-0902-866X
임범진(Lim, Beom Jin) ORCID logo https://orcid.org/0000-0003-2856-0133
정현주(Jeong, Hyeon Joo) ORCID logo https://orcid.org/0000-0002-9695-1227
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/151859
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