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Does serum uric acid act as a modulator of cerebrospinal fluid Alzheimer's disease biomarker related cognitive decline?

 B. S. Ye  ;  W. W. Lee  ;  J. H. Ham  ;  J. J. Lee  ;  P. H. Lee  ;  Y. H. Sohn 
 EUROPEAN JOURNAL OF NEUROLOGY, Vol.23(5) : 948-957, 2016 
Journal Title
Issue Date
Aged ; Aged, 80 and over ; Alzheimer Disease/blood ; Alzheimer Disease/cerebrospinal fluid ; Alzheimer Disease/complications ; Alzheimer Disease/diagnosis* ; Biomarkers/blood ; Biomarkers/cerebrospinal fluid ; Cognition Disorders/blood ; Cognition Disorders/cerebrospinal fluid ; Cognition Disorders/diagnosis* ; Cognition Disorders/etiology ; Cognitive Dysfunction/blood ; Cognitive Dysfunction/cerebrospinal fluid ; Cognitive Dysfunction/diagnosis* ; Cognitive Dysfunction/etiology ; Databases, Factual ; Female ; Humans ; Male ; Middle Aged ; Neuropsychological Tests ; Uric Acid/blood*
Alzheimer's disease ; antioxidant ; cerebrospinal fluid ; cognitive decline ; mild cognitive impairment ; uric acid
BACKGROUND AND PURPOSE: The association of serum uric acid, cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) and longitudinal cognitive decline was evaluated using the AD Neuroimaging Initiative database.

METHODS: In 271 healthy subjects, 596 mild cognitive impairment patients and 197 AD patients, serum uric acid and CSF AD biomarkers were measured at baseline, and Mini-Mental State Examination and AD Assessment Scale - Cognitive Subscale (ADAS-cog) were assessed serially (mean duration, 2.9 years). The effect of uric acid on longitudinal cognitive decline was evaluated using linear mixed effect models for Mini-Mental State Examination and ADAS-cog scores in female and male subjects separately, with possible confounders controlled (model 1). To determine the effects of uric acid independent of CSF biomarker (Aβ1-42 or tau) and to test whether the detrimental effects of CSF biomarker differ according to uric acid, CSF biomarker and its interaction with uric acid were further included in model 1 (model 2).

RESULTS: Higher levels of uric acid were associated with slower cognitive decline, particularly in the mild cognitive impairment and dementia subgroups, and more prominently in female subjects. Model 2 with CSF Aβ1-42 showed that higher levels of uric acid were associated with a slower cognitive decline and alleviated the detrimental effect of Aβ1-42 on cognitive decline. Model 2 with CSF tau showed that higher levels of uric acid alleviated the detrimental effect of tau on cognitive decline in female subjects but not in male subjects.

CONCLUSION: Higher levels of uric acid had protective effects on longitudinal cognitive decline independent of and interactively with CSF AD biomarkers.
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1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Sohn, Young Ho(손영호) ORCID logo https://orcid.org/0000-0001-6533-2610
Ye, Byoung Seok(예병석) ORCID logo https://orcid.org/0000-0003-0187-8440
Lee, Jae Jung(이재정)
Lee, Phil Hyu(이필휴) ORCID logo https://orcid.org/0000-0001-9931-8462
Ham, Jee Hyun(함지현)
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