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Does serum uric acid act as a modulator of cerebrospinal fluid Alzheimer's disease biomarker related cognitive decline?

DC Field Value Language
dc.contributor.author손영호-
dc.contributor.author함지현-
dc.contributor.author예병석-
dc.contributor.author이재정-
dc.contributor.author이필휴-
dc.date.accessioned2017-10-26T07:18:01Z-
dc.date.available2017-10-26T07:18:01Z-
dc.date.issued2016-
dc.identifier.issn1351-5101-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/151854-
dc.description.abstractBACKGROUND AND PURPOSE: The association of serum uric acid, cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) and longitudinal cognitive decline was evaluated using the AD Neuroimaging Initiative database. METHODS: In 271 healthy subjects, 596 mild cognitive impairment patients and 197 AD patients, serum uric acid and CSF AD biomarkers were measured at baseline, and Mini-Mental State Examination and AD Assessment Scale - Cognitive Subscale (ADAS-cog) were assessed serially (mean duration, 2.9 years). The effect of uric acid on longitudinal cognitive decline was evaluated using linear mixed effect models for Mini-Mental State Examination and ADAS-cog scores in female and male subjects separately, with possible confounders controlled (model 1). To determine the effects of uric acid independent of CSF biomarker (Aβ1-42 or tau) and to test whether the detrimental effects of CSF biomarker differ according to uric acid, CSF biomarker and its interaction with uric acid were further included in model 1 (model 2). RESULTS: Higher levels of uric acid were associated with slower cognitive decline, particularly in the mild cognitive impairment and dementia subgroups, and more prominently in female subjects. Model 2 with CSF Aβ1-42 showed that higher levels of uric acid were associated with a slower cognitive decline and alleviated the detrimental effect of Aβ1-42 on cognitive decline. Model 2 with CSF tau showed that higher levels of uric acid alleviated the detrimental effect of tau on cognitive decline in female subjects but not in male subjects. CONCLUSION: Higher levels of uric acid had protective effects on longitudinal cognitive decline independent of and interactively with CSF AD biomarkers.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherWiley-
dc.relation.isPartOfEUROPEAN JOURNAL OF NEUROLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHAlzheimer Disease/blood-
dc.subject.MESHAlzheimer Disease/cerebrospinal fluid-
dc.subject.MESHAlzheimer Disease/complications-
dc.subject.MESHAlzheimer Disease/diagnosis*-
dc.subject.MESHBiomarkers/blood-
dc.subject.MESHBiomarkers/cerebrospinal fluid-
dc.subject.MESHCognition Disorders/blood-
dc.subject.MESHCognition Disorders/cerebrospinal fluid-
dc.subject.MESHCognition Disorders/diagnosis*-
dc.subject.MESHCognition Disorders/etiology-
dc.subject.MESHCognitive Dysfunction/blood-
dc.subject.MESHCognitive Dysfunction/cerebrospinal fluid-
dc.subject.MESHCognitive Dysfunction/diagnosis*-
dc.subject.MESHCognitive Dysfunction/etiology-
dc.subject.MESHDatabases, Factual-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeuropsychological Tests-
dc.subject.MESHUric Acid/blood*-
dc.titleDoes serum uric acid act as a modulator of cerebrospinal fluid Alzheimer's disease biomarker related cognitive decline?-
dc.typeArticle-
dc.publisher.locationEngland-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Neurology-
dc.contributor.googleauthorB. S. Ye-
dc.contributor.googleauthorW. W. Lee-
dc.contributor.googleauthorJ. H. Ham-
dc.contributor.googleauthorJ. J. Lee-
dc.contributor.googleauthorP. H. Lee-
dc.contributor.googleauthorY. H. Sohn-
dc.identifier.doi10.1111/ene.12969-
dc.contributor.localIdA04338-
dc.contributor.localIdA04603-
dc.contributor.localIdA03082-
dc.contributor.localIdA03270-
dc.contributor.localIdA01982-
dc.relation.journalcodeJ00830-
dc.identifier.eissn1468-1331-
dc.identifier.pmid26917248-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/ene.12969/abstract-
dc.subject.keywordAlzheimer's disease-
dc.subject.keywordantioxidant-
dc.subject.keywordcerebrospinal fluid-
dc.subject.keywordcognitive decline-
dc.subject.keywordmild cognitive impairment-
dc.subject.keyworduric acid-
dc.contributor.alternativeNameSohn, Young Ho-
dc.contributor.alternativeNameHam, Jee Hyun-
dc.contributor.alternativeNameYe, Byoung Seok-
dc.contributor.alternativeNameLee, Jae Jung-
dc.contributor.alternativeNameLee, Phil Hyu-
dc.contributor.affiliatedAuthorHam, Jee Hyun-
dc.contributor.affiliatedAuthorYe, Byoung Seok-
dc.contributor.affiliatedAuthorLee, Jae Jung-
dc.contributor.affiliatedAuthorLee, Phil Hyu-
dc.contributor.affiliatedAuthorSohn, Young Ho-
dc.citation.volume23-
dc.citation.number5-
dc.citation.startPage948-
dc.citation.endPage957-
dc.identifier.bibliographicCitationEUROPEAN JOURNAL OF NEUROLOGY, Vol.23(5) : 948-957, 2016-
dc.date.modified2017-10-24-
dc.identifier.rimsid46179-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers

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