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High dose and compartmental target volume may improve patient outcome after radiotherapy for pelvic bone metastases from hepatocellular carcinoma

 Taehyung Kim  ;  Hye Jung Cha  ;  Jun Won Kim  ;  Jinsil Seong  ;  Ik Jae Lee 
 ONCOTARGET , Vol.7(33) : 53921-53929, 2016 
Journal Title
Issue Date
Adult ; Aged ; Bone Neoplasms/mortality ; Bone Neoplasms/radiotherapy* ; Bone Neoplasms/secondary* ; Carcinoma, Hepatocellular/mortality ; Carcinoma, Hepatocellular/radiotherapy* ; Carcinoma, Hepatocellular/secondary* ; Disease-Free Survival ; Female ; Humans ; Kaplan-Meier Estimate ; Liver Neoplasms/mortality ; Liver Neoplasms/pathology* ; Male ; Middle Aged ; Pain Management/methods ; Pelvic Bones/pathology ; Pelvic Bones/radiation effects ; Radiotherapy/adverse effects ; Radiotherapy/methods ; Radiotherapy Dosage ; Retrospective Studies
compartmental target volume ; hepatocellular carcinoma ; local control ; pelvic bone metastasis ; radiotherapy
PURPOSE: Pelvic bone metastases are difficult to treat because of complex pelvic bone anatomy and the proximity of normal organs. The adequacy of radiation dose and field coverage was evaluated. PATIENTS AND METHODS: We analyzed 146 cases of pelvic bone metastases from HCC treated with radiotherapy (RT). Bone metastases were confirmed using CT/MRI. Subjective pain response was assessed using the visual analogue scale, and treatment-related toxicity with the Common Terminology Criteria for Adverse Events v3.0. Local failure free survival (LFFS) and overall survival were estimated using the Kaplan-Meier method. RESULTS: The local control rate was 80.1% and the pain control rate was 68.5%. Compartmental target volume (CTV), encompassing the whole compartment of the involved bone, was found to be a significant factor (1-year LFFS, 78% vs. 50%; p=0.001). Sites of metastasis were categorized as either upper or lower pelvic bone; both categories showed improved local control with CTV. Metastatic lesions that received more than 50 Gy of EQD2 showed more partial response in pain after RT (58% vs. 79%; p=0.007). No patient showed toxicity higher than Grade IV. CONCLUSION: Compartmental RT targeted to the involved bone was associated with improved local control and LFFS. High-dose radiation was associated with an improved treatment response.
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1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jun Won(김준원) ORCID logo https://orcid.org/0000-0003-1358-364X
Seong, Jin Sil(성진실) ORCID logo https://orcid.org/0000-0003-1794-5951
Lee, Ik Jae(이익재) ORCID logo https://orcid.org/0000-0001-7165-3373
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