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The effect of prolonged breast-feeding on the development of postmenopausal osteoporosis in population with insufficient calcium intake and vitamin D level

Authors
 B. H. Yun  ;  S. J. Chon  ;  Y. S. Choi  ;  S. Cho  ;  B. S. Lee  ;  S. K. Seo 
Citation
 OSTEOPOROSIS INTERNATIONAL, Vol.27(9) : 2745-2753, 2016 
Journal Title
 OSTEOPOROSIS INTERNATIONAL 
ISSN
 0937-941X 
Issue Date
2016
MeSH
Aged ; Bone Density* ; Breast Feeding/adverse effects* ; Calcium/administration & dosage* ; Female ; Humans ; Middle Aged ; Nutrition Surveys ; Osteoporosis, Postmenopausal/epidemiology* ; Republic of Korea ; Vitamin D/blood*
Keywords
Breast-feeding ; Calcium intake ; Menopause ; Osteoporosis ; Vitamin D deficiency
Abstract
Breast-feeding affects bone metabolism and calcium homeostasis, and prolonged breast-feeding may influence the development of postmenopausal osteoporosis, particularly in highly susceptible populations. The study determined that breast-feeding may be a risk factor for postmenopausal osteoporosis, especially in people with low calcium intakes and vitamin D deficiencies. INTRODUCTION: The purpose of this study was to determine whether breast-feeding is a risk factor in the development of postmenopausal osteoporosis, especially in highly susceptible population. METHODS: The study was performed using data from the 2010 to 2011 Korea National Health and Nutrition Examination Survey, and it included 1231 postmenopausal women who were aged between 45 and 70 years. Osteoporosis was defined using the World Health Organization's T-score criteria, namely, a T-score of ≤-2.5 at the femoral neck or the lumbar spine. The patients' ages, body mass indexes, daily calcium intakes, serum vitamin D levels, exercise levels, smoking histories, and reproductive factors relating to menarche, menopause, delivery, breast-feeding, hormone treatment, and oral contraceptive use were evaluated. Comparisons between the osteoporosis and non-osteoporosis groups were undertaken using Student's t test and the chi-square test, and logistic regression models were built. RESULTS: A significant increase in the risk of osteoporosis was apparent in postmenopausal women with prolonged breast-feeding histories (≥24 months) (model 1: odds ratio [OR]?=?2.489; 95 % confidence interval [CI]?=?1.111 to 5.578, p?=?0.027; model 2: OR?=?2.503; 95 % CI?=?1.118 to 5.602, p?=?0.026; model 3: OR?=?2.825; 95 % CI?=?1.056 to 7.56, p?=?0.039), particularly in those with inadequate serum vitamin D levels and calcium intakes (<800 mg/day). CONCLUSIONS: Breast-feeding seems to increase the risk of postmenopausal osteoporosis; however, its impact may not be definitive in women with sufficient vitamin D levels and calcium intakes. Therefore, sufficient calcium intakes and adequate vitamin D levels may be important to prevent osteoporosis in postmenopausal women that is derived from breast-feeding.
Full Text
https://link.springer.com/article/10.1007%2Fs00198-016-3585-8
DOI
10.1007/s00198-016-3585-8
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Seo, Seok Kyo(서석교) ORCID logo https://orcid.org/0000-0003-3404-0484
Yun, Bo Hyon(윤보현) ORCID logo https://orcid.org/0000-0001-5703-797X
Lee, Byung Seok(이병석) ORCID logo https://orcid.org/0000-0001-6001-2079
Cho, Si Hyun(조시현) ORCID logo https://orcid.org/0000-0003-2718-6645
Choi, Young Sik(최영식) ORCID logo https://orcid.org/0000-0002-1157-4822
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/151850
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