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Upfront Systemic Chemotherapy and Short-Course Radiotherapy with Delayed Surgery for Locally Advanced Rectal Cancer with Distant Metastases: Outcomes, Compliance, and Favorable Prognostic Factors

Authors
 Hong In Yoon  ;  Woong Sub Koom  ;  Tae Hyung Kim  ;  Joong Bae Ahn  ;  Minkyu Jung  ;  Tae Il Kim  ;  Hoguen Kim  ;  Sang Joon Shin  ;  Nam Kyu Kim 
Citation
 PLoS One, Vol.11(8) : e0161475, 2016 
Journal Title
 PLoS One 
Issue Date
2016
MeSH
Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/therapeutic use ; Combined Modality Therapy/methods ; Disease-Free Survival ; Female ; Humans ; Male ; Middle Aged ; Neoplasm Metastasis ; Prognosis ; Rectal Neoplasms/diagnosis ; Rectal Neoplasms/pathology ; Rectal Neoplasms/therapy* ; Rectum/surgery ; Retrospective Studies ; Survival Analysis
Abstract
PURPOSE/OBJECTIVE(S): Optimal treatment for locally advanced rectal cancer (LARC) with distant metastasis remains elusive. We aimed to evaluate upfront systemic chemotherapy and short-course radiotherapy (RT) followed by delayed surgery for such patients, and to identify favorable prognostic factors. MATERIALS/METHODS: We retrospectively reviewed 50 LARC patients (cT4 or cT3, <2 mm from the mesorectal fascia) with synchronous metastatic disease. The primary endpoint was progression-free survival (PFS). The secondary endpoints were overall survival, treatment-related toxicity, and compliance. We considered P values <0.05 significant. RESULTS: At 22 months median follow-up, the median PFS time was 16 months and the 2-year PFS rate was 34.8%. Thirty-five patients who received radical surgery for primary and metastatic tumors were designated the curable group. Six patients with clinical complete response (ypCR) of metastases who underwent radical surgery for only the primary tumor were classified as potentially curable. Nine patients who received no radical surgery (3 received palliative surgery) were deemed the palliative group. The ypCR rate among surgery patients was 13.6%. PFS rates for the curable or potentially curable groups were significantly longer than that of the palliative group (P<0.001). On multivariate analysis, solitary organ metastasis and R0 status were independent prognostic factors for PFS. CONCLUSIONS: These findings demonstrated that a strong possibility that upfront chemotherapy and short-course RT with delayed surgery are an effective alternative treatment for LARC with potentially resectable distant metastasis, owing to achievement of pathologic down-staging, R0 resection, and favorable compliance and toxicity, despite the long treatment duration.
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DOI
10.1371/journal.pone.0161475
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Koom, Woong Sub(금웅섭) ORCID logo https://orcid.org/0000-0002-9435-7750
Kim, Nam Kyu(김남규) ORCID logo https://orcid.org/0000-0003-0639-5632
Kim, Tae Il(김태일) ORCID logo https://orcid.org/0000-0003-4807-890X
Kim, Ho Keun(김호근)
Shin, Sang Joon(신상준) ORCID logo https://orcid.org/0000-0001-5350-7241
Ahn, Joong Bae(안중배) ORCID logo https://orcid.org/0000-0001-6787-1503
Yoon, Hong In(윤홍인) ORCID logo https://orcid.org/0000-0002-2106-6856
Jung, Min Kyu(정민규) ORCID logo https://orcid.org/0000-0001-8281-3387
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/151840
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