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Serum ferritin levels are associated with arterial stiffness in healthy Korean adults

Authors
 Ji Yoon Ha  ;  Min Kyung Kim  ;  Shinae Kang  ;  Ji Sun Nam  ;  Chul Woo Ahn  ;  Kyung Rae Kim  ;  Jong Suk Park 
Citation
 VASCULAR MEDICINE, Vol.21(4) : 325-330, 2016 
Journal Title
 VASCULAR MEDICINE 
ISSN
 1358-863X 
Issue Date
2016
MeSH
Adult ; Ankle Brachial Index ; Asian Continental Ancestry Group* ; Asymptomatic Diseases ; Atherosclerosis/blood ; Atherosclerosis/diagnosis ; Atherosclerosis/ethnology* ; Atherosclerosis/physiopathology ; Biomarkers/blood ; Cross-Sectional Studies ; Female ; Ferritins/blood* ; Healthy Volunteers ; Humans ; Linear Models ; Logistic Models ; Male ; Middle Aged ; Multivariate Analysis ; Odds Ratio ; Pulse Wave Analysis ; Republic of Korea ; Risk Factors ; Vascular Stiffness*
Keywords
arterial stiffness ; atherosclerosis ; ferritin
Abstract
Although an association between serum ferritin and atherosclerosis has been suggested, limited epidemiologic data are available regarding the association between ferritin and arterial stiffness in healthy adults. A total of 2932 healthy subjects were enrolled in this study. Anthropometric and biochemical profiles including ferritin were measured. The arterial stiffness was measured using brachial-ankle pulse wave velocity (baPWV). Serum ferritin levels were classified into quartiles and baPWV values gradually increased with each ferritin quartile. Multiple regression analysis showed that ferritin levels were independently correlated with baPWV. After adjusting for multiple risk factors, as compared with the lowest quartile, the odds ratios for high baPWV (>75(th) percentile) were 1.15 (0.84-1.56), 1.37 (0.97-1.73), and 1.46 (1.29-2.17) among men (p for trend < 0.05) and 1.24 (0.87-1.79), 1.53 (1.09-2.16), and 1.80 (1.25-2.82) among women (p for trend < 0.05), for the second, third, and fourth quartiles of ferritin, respectively. In conclusion, serum ferritin levels are independently associated with arterial stiffness in healthy Korean adults.
Full Text
http://journals.sagepub.com/doi/abs/10.1177/1358863X16629728
DOI
10.1177/1358863X16629728
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Shin Ae(강신애) ORCID logo https://orcid.org/0000-0002-9719-4774
Kim, Kyung Rae(김경래)
Kim, Min Kyung(김민경)
Nam, Ji Sun(남지선) ORCID logo https://orcid.org/0000-0001-8655-5258
Park, Jong Suk(박종숙) ORCID logo https://orcid.org/0000-0002-5385-1373
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Ha, Ji Yoon(하지윤)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/151783
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