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Hair sterol signatures coupled to multivariate data analysis reveal an increased 7β-hydroxycholesterol production in cognitive impairment

Authors
 Hyun-Hwa Son  ;  Do-Yup Lee  ;  Hong Seog Seo  ;  Jihyeon Jeong  ;  Ju-Yeon Moon  ;  Jung-Eun Lee  ;  Bong Chul Chung  ;  Eosu Kim  ;  Man Ho Choi 
Citation
 Journal of Steroid Biochemistry and Molecular Biology, Vol.155(Pt A) : 9-17, 2016 
Journal Title
 Journal of Steroid Biochemistry and Molecular Biology 
ISSN
 0960-0760 
Issue Date
2016
MeSH
Aged ; Alzheimer Disease/metabolism* ; Biomarkers/analysis ; Case-Control Studies ; Cognitive Dysfunction/metabolism* ; Female ; Gas Chromatography-Mass Spectrometry ; Hair/chemistry* ; Hair/metabolism ; Humans ; Hydroxycholesterols/metabolism* ; Multivariate Analysis ; Reproducibility of Results ; Sterols/analysis* ; Sterols/metabolism
Keywords
7β-hydroxycholesterol ; Alzheimer’s disease ; Cholesterol signatures ; Hair ; Mini-Mental State Examination
Abstract
Altered cholesterol metabolism could be associated with cognitive impairment. The quantitative profiling of 19 hair sterols was developed using gas chromatography-mass spectrometry coupled to multivariate data analysis. The limit of quantification of all sterols ranged from 5 to 20 ng/g, while the calibration linearity was higher than 0.98. The precision (% CV) and accuracy (% bias) ranged from 3.2% to 9.8% and from 83.2% to 119.4%, respectively. Among the sterols examined, 8 were quantitatively detected from two strands of 3-cm-long scalp hair samples of female participants, including mild cognitive impairment (MCI, n=15), Alzheimer's disease (AD, n=31), and healthy controls (HC, n=36). The cognitive impairment (MCI or AD) was correlated with a higher metabolic rate than that of HCs based on 7β-hydroxycholesterol (P<0.005). Significant negative correlations (r=-0.822) were detected between Mini-Mental State Examination (MMSE) scores and hair sample metabolic ratios of 7β-hydroxycholesterol to cholesterol, which is an accepted, sensitive, and specific tool for discriminating HCs from individuals with MCI or AD. In conclusion, improved diagnostic values can be obtained using hair sterol signatures coupled with MMSE scores. This method may prove useful for predictive diagnosis in population screening of cognitive impairment.
Full Text
http://www.sciencedirect.com/science/article/pii/S0960076015300844
DOI
10.1016/j.jsbmb.2015.09.024
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
김어수(Kim, Eosu) ORCID logo https://orcid.org/0000-0001-9472-9465
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/151733
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