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Dynamic Axonal Translation in Developing and Mature Visual Circuits

DC Field Value Language
dc.contributor.author정호성-
dc.date.accessioned2017-10-26T07:08:20Z-
dc.date.available2017-10-26T07:08:20Z-
dc.date.issued2016-
dc.identifier.issn0092-8674-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/151652-
dc.description.abstractLocal mRNA translation mediates the adaptive responses of axons to extrinsic signals, but direct evidence that it occurs in mammalian CNS axons in vivo is scant. We developed an axon-TRAP-RiboTag approach in mouse that allows deep-sequencing analysis of ribosome-bound mRNAs in the retinal ganglion cell axons of the developing and adult retinotectal projection in vivo. The embryonic-to-postnatal axonal translatome comprises an evolving subset of enriched genes with axon-specific roles, suggesting distinct steps in axon wiring, such as elongation, pruning, and synaptogenesis. Adult axons, remarkably, have a complex translatome with strong links to axon survival, neurotransmission, and neurodegenerative disease. Translationally co-regulated mRNA subsets share common upstream regulators, and sequence elements generated by alternative splicing promote axonal mRNA translation. Our results indicate that intricate regulation of compartment-specific mRNA translation in mammalian CNS axons supports the formation and maintenance of neural circuits in vivo.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherCell Press-
dc.relation.isPartOfCELL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAlternative Splicing-
dc.subject.MESHAnimals-
dc.subject.MESHAxons/metabolism*-
dc.subject.MESHGene Expression Regulation, Developmental-
dc.subject.MESHMice-
dc.subject.MESHProtein Biosynthesis*-
dc.subject.MESHProteome/analysis-
dc.subject.MESHProteome/metabolism*-
dc.subject.MESHRNA, Messenger/analysis-
dc.subject.MESHRNA, Messenger/metabolism-
dc.subject.MESHRetinal Ganglion Cells/metabolism*-
dc.subject.MESHRibosomes/metabolism-
dc.subject.MESHSuperior Colliculi/metabolism-
dc.subject.MESHSynaptic Transmission-
dc.titleDynamic Axonal Translation in Developing and Mature Visual Circuits-
dc.typeArticle-
dc.publisher.locationUnited States-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Anatomy-
dc.contributor.googleauthorToshiaki Shigeoka-
dc.contributor.googleauthorHosung Jung-
dc.contributor.googleauthorJane Jung-
dc.contributor.googleauthorBenita Turner-Bridger-
dc.contributor.googleauthorJiyeon Ohk-
dc.contributor.googleauthorJulie Qiaojin Lin-
dc.contributor.googleauthorPaul S. Amieux-
dc.contributor.googleauthorChristine E. Holt-
dc.identifier.doi10.1016/j.cell.2016.05.029-
dc.contributor.localIdA03786-
dc.relation.journalcodeJ00472-
dc.identifier.eissn1097-4172-
dc.identifier.pmid27321671-
dc.identifier.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930487/?report=printable-
dc.contributor.alternativeNameJung, Ho Sung-
dc.contributor.affiliatedAuthorJung, Ho Sung-
dc.citation.volume166-
dc.citation.number1-
dc.citation.startPage181-
dc.citation.endPage192-
dc.identifier.bibliographicCitationCELL, Vol.166(1) : 181-192, 2016-
dc.date.modified2017-10-24-
dc.identifier.rimsid45666-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers

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