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Hyperuricemia and uncontrolled hypertension in treated hypertensive patients: K-MetS Study

Authors
 Jaelim Cho  ;  Changsoo Kim  ;  Dae Ryong Kang  ;  Jeong Bae Park 
Citation
 MEDICINE, Vol.95(28) : 4177, 2016 
Journal Title
 MEDICINE 
ISSN
 0025-7974 
Issue Date
2016
MeSH
Adult ; Aged ; Biphenyl Compounds/therapeutic use* ; Female ; Humans ; Hypertension/drug therapy* ; Hyperuricemia/epidemiology* ; Male ; Middle Aged ; Prospective Studies ; Pyrimidines/therapeutic use* ; Republic of Korea/epidemiology ; Risk Factors ; Tetrazoles/therapeutic use* ; Treatment Outcome
Keywords
blood pressure ; fimasartan ; hypertension ; hyperuricemia ; metabolic syndrome
Abstract
Previous epidemiological studies have suggested that uric acid is an independent risk factor for incident hypertension, whereas few studies have evaluated the effect of hyperuricemia on blood pressure control in hypertensive patients. We investigated whether hyperuricemia predicts uncontrolled hypertension through a large-scale prospective cohort study with hypertensive patients treated with fimasartan in the Republic of Korea (the Kanarb-Metabolic Syndrome study).Of the 10,601 hypertensive patients who were recruited from 582 private clinics and 11 university hospitals at baseline, 7725 completed the follow-up after 3 months of fimasartan medication, and 6506 were included in the analysis after excluding those with missing values. We estimated the risk of uncontrolled hypertension after 3 months (≥130/80 mm Hg in those with diabetes or chronic renal failure and ≥140/90 mm Hg in the remaining patients) related with baseline hyperuricemia (serum uric acid ≥7?mg/dL in males ≥6?mg/dL in females) using multiple logistic regression models.Hyperuricemia increased the risk of uncontrolled hypertension after 3 months of fimasartan medication (odds ratio, 1.247; 95% confidence interval, 1.063-1.462). Males in the highest quartile of uric acid level were at a 1.322 (95% confidence interval, 1.053-1.660) times higher risk of uncontrolled hypertension in reference to the lowest quartile; the same analyses in females were not significant. Patients without metabolic syndrome had significantly higher odds of uncontrolled hypertension with hyperuricemia (odds ratio, 1.328; 95% confidence interval, 1.007-1.751).Hyperuricemia predicted uncontrolled hypertension even after 3 months of fimasartan treatment in hypertensive patients.
DOI
10.1097/MD.0000000000004177
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chang Soo(김창수) ORCID logo https://orcid.org/0000-0002-5940-5649
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/151625
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