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MuSK 항체 양성을 보이는 혈청음성 중증근무력증 환자의 임상적 특징

Other Titles
 Clinical Features of MuSK Antibody Positive Seronegative Myasthenia Gravis 
Authors
 이지영  ;  성정준  ;  오동훈  ;  민주홍  ;  김현정  ;  박종하  ;  최영철  ;  김성훈  ;  A. Vincent  ;  이광우 
Citation
 Journal of the Korean Neurological Association, Vol.23(6) : 792-795, 2005 
Journal Title
Journal of the Korean Neurological Association
ISSN
 1738-1428 
Issue Date
2005
Abstract
Background: A variable proportion of seronegative myasthenia gravis (SNMG) patients have antibodies to the muscle-specific tyrosine kinase (MuSK). Although several reports from Western countries suggest differences in the clinical features of MuSK antibody-positive and -negative SNMG patients, there have been no reports about these patients in Korea.

Methods: We performed the first survey of MuSK antibodies in Korea, measuring MuSK antibodies by commercial preparations (RSR Ltd) in the serum of SNMG patients who registered at the Seoul National University Hospital from October 2003 to January 2004, and identified clinical features and treatment responses prospectively until October 2004 using double blind method.

Results: Twenty-three (15 generalized and eight ocular MG, 15 men and eight women) SNMG patients with the ages from 1 to 60 years, (mean 36.24±16.82 years), were included. None of 8 ocular SNMG had MuSK antibody, whereas MuSK antibody was present in four (26.7%) of 15 generalized SNMG. All four MuSK positive patients were females, with pharyngeal and respiratory muscle weakness, and required immunosuppressive treatment in addition to acetylcholine esterase inhibitors. However, the overall disease severity and the age of onset did not show significant differences between MuSK antibody-positive and -negative SNMG patients and the responses to treatment were equally favorable.

Conclusions: Our study showed the lower rate of MuSK antibodies in SNMG than the previous reports. However it seems to require large multicenter survey to confirm the possibilities of geographical or ethnical differences in the future.
Files in This Item:
T200501464.pdf Download
DOI
OAK-2005-06297
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Choi, Young Chul(최영철) ORCID logo https://orcid.org/0000-0001-5525-6861
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/151547
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