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Conventional papanicolaou smear, fluid-based thin-layer method와 cervicography의 비교 분석

Other Titles
 Comparative analysis of conventional Papanicolaou smear, fluid-based thin-Layer method and cervicography 
Authors
 김유리  ;  김영태  ;  김성훈  ;  김재훈  ;  김재욱  ;  박용원 
Citation
 Korean Journal of Obstetrics and Gynecology (대한산부인과학회지), Vol.48(12) : 2932-2940, 2005 
Journal Title
Korean Journal of Obstetrics and Gynecology(대한산부인과학회지)
ISSN
 1738-5628 
Issue Date
2005
MeSH
Papanicolaou smear ; Fluid-based thin-layer method ; Cervicography
Keywords
Papanicolaou smear ; Fluid-based thin-layer method ; Cervicography
Abstract
Objective: The aim of this study was to evaluate the diagnostic performance of Papanicolaou smear, a fluid-based thin-layer method and cervicography as a primary screening test of cervical cancer.

Methods: Among all patients screened by cervicography from January 2003 to Jun 2004, 357 patients who were examined by the Pap smear or ThinPrep Pap test and cervicography as a screening procedure for cervical cancer and taken by the subsequent colposcopy directed biopsy as required, were analyzed with a receiver operating characteristic (ROC) curves and divided into two groups: conventional Pap group (n=256) and ThinPrep group (n=101).

Results: ThinPrep group showed higher sensitivity (86.0%>64.0%), higher negative predictive value (78.4%>65.0%), lower false negative rate (21.6%<35.0%), but lower specificity (66.0%<79.5%), lower positive predictive value (66.2%<78.8%), higher false positive rate (33.8%> 21.2%). Cervicography showed no significant difference between each group. In ThinPrep group, ROC curves showed the AUC of ThinPrep 0.848, the AUC of cervicography 0.585. ThinPrep group was higher with statistical significance (P=0.0001). In conventional Pap group, the result of ROC curves showed the AUC of conventional Pap 0.750, the AUC of cervicography 0.680. Conventional Pap group was somewhat higher but there was no statistical significance (P=0.0975).

Conclusion: ThinPrep Pap test showed significantly higher diagnostic accuracy than cervicography. However, conventional Pap test revealed somewhat better screening performance than cervicography without statistical significance. Therefore, the ThinPrep Pap test might be an effective screening test in detecting precancerous lesion of the uterine cervix.
Files in This Item:
T200501481.pdf Download
DOI
OAK-2005-06346
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sung Hoon(김성훈) ORCID logo https://orcid.org/0000-0002-1645-7473
Kim, Young Tae(김영태) ORCID logo https://orcid.org/0000-0002-7347-1052
Kim, Jae Wook(김재욱)
Kim, Jae Hoon(김재훈) ORCID logo https://orcid.org/0000-0001-6599-7065
Park, Yong Won(박용원)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/151492
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