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난치성 소아 간질에서 치료 방법에 따른 성적

Other Titles
 Outcomes of Therapeutic Modalities for Intractable Childhood Epilepsy 
Authors
 강훈철  ;  권지원  ;  황용순  ;  김흥동  ;  박상근 
Citation
 Journal of the Korean Child Neurology Society (대한소아신경학회지), Vol.13(2) : 151-164, 2005 
Journal Title
 Journal of the Korean Child Neurology Society (대한소아신경학회지) 
ISSN
 1226-6884 
Issue Date
2005
MeSH
Intractable childhood epilepsy ; Anti-epileptic drugs ; Prednisolone ; Ketogenic diet ; Epilepsy surgery ; Vagus nerve stimulation
Keywords
Intractable childhood epilepsy ; Anti-epileptic drugs ; Prednisolone ; Ketogenic diet ; Epilepsy surgery ; Vagus nerve stimulation
Abstract
Purpose : This study sought to evaluate the clinical outcomes of various therapeutic modalities, including newly-developed anti-epileptic drugs (AEDs), prednisolone, ketogenic diet (KD) epilepsy surgery, and vagus nerve stimulation (VNS), in treating intractable childhood epilepsy. Methods : Data of refractory epilepsy patients (n=297) treated from July 1995 through April 2003 at the epilepsy center of Sanggye Paik Hospital were retrospectively analyzed. Results : Newly-developed AEDs were primarily prescribed to 290 patients, although only 20 patients (6.9%) maintained a seizure- free state. Of 138 patients for whom prednisolone was prescribed, 58 patients (42.0%) showed complete seizure controls while 41 patients experienced relapse. KD was attempted and evaluated at 12 months in 162 patients, at which time 74 (45.7%) remained on the diet and 68 (42.0%) showed seizure reduction of greater than 50%, including 37 (22.8%) who were completely seizure free. Epilepsy surgery was undergone in 38 patients, and Engel class I was identified in 25 (65.8%) patients. VNS was administered to five patients, only two of whom obtained a seizure reduction of more than 50%. Result : Taken together, these findings suggest that considerable controls over intractable childhood epilepsy can be gained through KD and epilepsy surgery, whereas prednisolone treatment leads to somewhat more frequent relapses, and newly-developed AEDs are comparatively limited in their controls of refractory epilepsy.
Full Text
http://scholar.dkyobobook.co.kr/searchDetail.laf?barcode=4010022737149
DOI
OAK-2005-06382
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Hoon Chul(강훈철) ORCID logo https://orcid.org/0000-0002-3659-8847
Kim, Heung Dong(김흥동) ORCID logo https://orcid.org/0000-0002-8031-7336
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/151470
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