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The effects on postoperative oral surgery pain by varying NSAID administration times: Comparison on effect of preemptive analgesia

Authors
 Young-Soo Jung  ;  Moon-Key Kim  ;  Yoo Jung Um  ;  Hyung-Sik Park  ;  Eui-Wung Lee  ;  Jeong-Wan Kang 
Citation
 ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY, Vol.100(5) : 559-563, 2005 
Journal Title
 ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY 
ISSN
 1079-2104 
Issue Date
2005
MeSH
Adolescent ; Adult ; Analysis of Variance ; Anti-Inflammatory Agents/administration & dosage* ; Benzofurans/administration & dosage* ; Chi-Square Distribution ; Double-Blind Method ; Facial Pain/drug therapy ; Female ; Humans ; Male ; Mandible ; Molar, Third/surgery* ; Pain, Postoperative/drug therapy* ; Pain, Postoperative/etiology ; Postoperative Care ; Preoperative Care ; Pyridines/administration & dosage* ; Time Factors ; Tooth Extraction/adverse effects* ; Tooth, Impacted/surgery
Keywords
16243240
Abstract
OBJECTIVE: Many studies on the efficacy of preemptive analgesia have been processed in different ways. But the value of preemptive analgesia is still controversial. The goal of this study was to compare analgesic effects of a nonsteroidal anti-inflammatory drug (NSAID) for oral surgical pain according to 3 different administration times. STUDY DESIGN: Using a randomized, parallel-group, single-center, and active-controlled test design, this study was conducted with 80 healthy patients undergoing a surgical removal of an impacted mandibular third molar requiring bone removal. The oral NSAID was first administered 1 hour preoperatively, or 1 hour postoperatively, or no scheduled administration pre- or postsurgery. Whenever patients felt at least moderate pain (score > or =5 on a 10-point scale) after surgery, they were instructed to take the same drug. Pain intensities and times to the first and second onsets of postoperative pain from the end of surgery were assessed for 24 hours. RESULTS: Of the 80 enrolled subjects in this study, 25 patients were assigned to the preemptive group, 26 to the posttreatment group, and 29 to the no-treatment group. The demographic distribution and duration of surgery in the 3 groups were statistically similar. The mean time to first onset of postoperative pain was significantly prolonged in the posttreatment group (277.2 minutes, P < .05) compared to the preemptive group (158.4 minutes) and the no-treatment group (196.5 minutes). The mean time to second onset of postoperative pain was not significantly different among the 3 groups. No significant statistical difference was found among the mean pain intensities at the first and second onsets of postoperative pain in the 3 groups. CONCLUSIONS: In this small selected group of subjects and limited study design, the analgesic effects of NSAID administered preoperatively were no longer effective for postoperative pain. The results in this population imply that scheduled postoperative analgesics before pain development are adequate for postoperative analgesia without preoperative administration.
Full Text
http://www.sciencedirect.com/science/article/pii/S1079210405001733
DOI
10.1016/j.tripleo.2005.02.065
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Jeong Wan(강정완) ORCID logo https://orcid.org/0000-0002-3945-8452
Park, Hyung Sik(박형식)
Lee, Eui Wung(이의웅)
Jung, Young Soo(정영수) ORCID logo https://orcid.org/0000-0001-5831-6508
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/151428
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