Cited 3 times in
Serotonin transporter mRNA expression in the dorsal raphe nucleus of a tumor bearing mouse
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 장정원 | - |
dc.date.accessioned | 2017-10-26T06:51:41Z | - |
dc.date.available | 2017-10-26T06:51:41Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/151415 | - |
dc.description.abstract | This study was conducted to determine if an oral squamous cell carcinoma alters mRNA expression of serotonin transporter (5-HTT) in the central nervous system. KB cell line derived from a human oral squamous cell carcinoma was inoculated into nude mice, and mRNA expression level of 5-HTT in the dorsal raphe nucleus (DRN) was examined by in situ hybridization when the tumor mass reached to -10% of total body weight. Plasma leptin levels were determined by radioimmunoassay method using a commercial kit. 5-HTT mRNA level was significantly decreased in the DRN of tumor bearing mice, compared to the age-matching non-tumor control. Plasma leptin level decreased concomitantly in tumor bearing mice. These results suggest that oral carcinoma may suppress 5-HTT gene expression in the central nervous system, perhaps in relation with decreased plasma leptin level. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isPartOf | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Body Weight | - |
dc.subject.MESH | Carcinoma, Squamous Cell/metabolism* | - |
dc.subject.MESH | Carcinoma, Squamous Cell/pathology | - |
dc.subject.MESH | DNA, Complementary | - |
dc.subject.MESH | Gene Expression Regulation, Neoplastic* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Leptin/blood | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Membrane Glycoproteins/genetics* | - |
dc.subject.MESH | Membrane Glycoproteins/metabolism | - |
dc.subject.MESH | Membrane Transport Proteins/genetics* | - |
dc.subject.MESH | Membrane Transport Proteins/metabolism | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred BALB C | - |
dc.subject.MESH | Mice, Nude | - |
dc.subject.MESH | Mouth Neoplasms/metabolism* | - |
dc.subject.MESH | Mouth Neoplasms/pathology | - |
dc.subject.MESH | Nerve Tissue Proteins/genetics* | - |
dc.subject.MESH | Nerve Tissue Proteins/metabolism | - |
dc.subject.MESH | RNA, Messenger/metabolism* | - |
dc.subject.MESH | Radioimmunoassay | - |
dc.subject.MESH | Raphe Nuclei/metabolism* | - |
dc.subject.MESH | Serotonin/metabolism | - |
dc.subject.MESH | Serotonin Plasma Membrane Transport Proteins | - |
dc.title | Serotonin transporter mRNA expression in the dorsal raphe nucleus of a tumor bearing mouse | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pharmacology (약리학교실) | - |
dc.contributor.googleauthor | Jeong Won Jahng | - |
dc.contributor.googleauthor | Si Ho Choi | - |
dc.contributor.googleauthor | Mi Joo Cha | - |
dc.contributor.googleauthor | Nam Youl Kim | - |
dc.contributor.googleauthor | Soon Jeong Hwang | - |
dc.contributor.googleauthor | Jong-Ho Lee | - |
dc.identifier.doi | 10.1038/emm.2005.9 | - |
dc.contributor.localId | A03467 | - |
dc.relation.journalcode | J00860 | - |
dc.identifier.eissn | 2092-6413 | - |
dc.identifier.pmid | 15761254 | - |
dc.subject.keyword | depression | - |
dc.subject.keyword | gene expression | - |
dc.subject.keyword | in situ hybridization | - |
dc.subject.keyword | leptin | - |
dc.subject.keyword | serotonin | - |
dc.subject.keyword | tumor | - |
dc.contributor.alternativeName | Jahng, Jeong Won | - |
dc.contributor.alternativeName | Jahng, Jeong Won | - |
dc.contributor.affiliatedAuthor | 장정원 | - |
dc.citation.volume | 37 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 65 | - |
dc.citation.endPage | 69 | - |
dc.identifier.bibliographicCitation | EXPERIMENTAL AND MOLECULAR MEDICINE, Vol.37(1) : 65-69, 2005 | - |
dc.date.modified | 2017-05-04 | - |
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