양성 위용종에서 Helicobacter pylori 제균치료 효과 : 예비연구

Abstract

Background/Aims: Evidence in the West indicates that eradication of Helicobacter pylori may lead to the disappearance of hyperplastic polyp in the stomach. However, there is limited data on the efficacy of H.pylori eradication for gastric polyp in Korea. We conducted a prospective study to evaluate whether benign gastric polyps would be changed in size after eradication of H.pylori. Methods: We enrolled 34 patients (11 men and 23 women) with H.pylori infection and benign gastric polyps diagnosed by endoscopic exam. Patients received a 7 days regimen of proton pump inhibitor, amoxicillin and clarithromycin for eradication and underwent following-up endoscopy for change of gastric polyp size in regular interval. Results: H. pylori was successfully eradicated without serious side effects in 31 of 34 patients (91.9%), and average size of gastric polyp decreased significantly between before and after H.pylori eradication (7.3 mm vs 3.6 mm p＜0.05). The polyps had disappeared completely in 12 patients (complete response, 35.2%) and regressed in 16 (partial response, 47.1%) of the 34 patients. Therefore response rate of gastric polyp after H. pylori eradication was 82.3%. Conclusions: Most benign gastric polyps disappeared or regressed after eradication of H.pylori. Thus, H. pylori eradication can be considered instead of endoscopic treatment in patients with benign gastric polyps and H. pylori infection.