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융모막 융모 샘플링 1,058예에 대한 임상 및 세포유전학 연구 : 21년(1984-2004년)간의 경험

Other Titles
 Chorionic Villus Sampling: Clinical and Cytogenetic Study of the First 1,058 Cases in YUMC from 1984 to 2004 years 
Authors
 양은석  ;  양영호  ;  박용원  ;  김세광 
Citation
 Korean Journal of Obstetrics and Gynecology (대한산부인과학회지), Vol.48(7) : 1654-1662, 2005 
Journal Title
Korean Journal of Obstetrics and Gynecology(대한산부인과학회지)
ISSN
 1738-5628 
Issue Date
2005
MeSH
Chorionic villus sampling ; Prenatal genetic diagnosis ; Fetal loss ; Congenital anomaly
Keywords
Chorionic villus sampling ; Prenatal genetic diagnosis ; Fetal loss ; Congenital anomaly
Abstract
Objective: This study was performed to evaluate the feasibility, accuracy and safety of Chorionic Villus Sampling (CVS).

Methods: We analyzed the outcome of 1,058 cases of CVS performed for prenatal genetic diagnosis between 7 and 12 weeks of gestation in the outpatient prenatal genetic clinic in Yonsei University Medical Center (1,030 cases by trans-cervical method and 28 cases by trans-abdominal). Fetal Karyotyping was obtained by direct or indirect culture methods using Gimsa and Gimsa-Banding.

Results: Advanced maternal age was the most common indication for CVS (34.7%). The overall sampling success rate was 98% (1040/ 1,058), representing 92.5% in 7 to 8 weeks, 98.0% in 9 to 10 weeks, and 98.9% in 11 to 12weeks of gestation. The majority of cases (94.6%) required one or two aspirations. Cytogenetic analysis routinely included direct overnight and long-term culture methods, which revealed 27 chromosomal abnormalities (2.6%). Of 1,040 cases in which CVS were successful, 989 delivered normal baby, 23 resulted in fetal loss, 25 had therapeutic termination (24 with chromosome abnormalities and 1 with normal chromosome with huge myoma), and 3 with chromosome abnormalities were loss to follow up. The overall fetal loss rate was 2.2% (23/1,058). No congenital anomalies were found to be related to CVS in these series.

Conclusion: When performed by experienced operators and cytogeneticists beyond 9 weeks of gestation, CVS is a feasible, accurate and safe method for prenatal genetic diagnosis capable of replacing genetic amniocentesis.
Files in This Item:
T200501115.pdf Download
DOI
OAK-2005-05483
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sei Kwang(김세광)
Park, Yong Won(박용원)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/151271
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