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혈청 CA-125, 초음파 및 양전자방출단층촬영술을 통한 골반 종물의 감별진단

Other Titles
 Differential diagnosis of pelvic masses with serum CA-125, ultrasound, and positron emission tomography 
 구자성  ;  김영태  ;  김성훈  ;  김재욱  ;  김재훈  ;  박용원  ;  김복자  ;  남은지  ;  윤미진 
 Korean Journal of Obstetrics and Gynecology (대한산부인과학회지), Vol.48(8) : 1926-1933, 2005 
Journal Title
Korean Journal of Obstetrics and Gynecology(대한산부인과학회지)
Issue Date
PET ; Ultrasonography ; CA-125 ; Ovarian tumor
PET ; Ultrasonography ; CA-125 ; Ovarian tumor
Objective: The purpose of this study was to evaluate whether positron emission tomography (PET) is more valid than transvaginal ultrasonography (TVS) or serum CA125 in differentiating malignant ovarian tumor from benign ovarian tumor.

Methods: Fifty patients with adnexal tumor were evaluated with PET, TVS and serum CA 125 before surgery. PET was used to determine the uptake of FDG (18F-2-fluoro-2-deoxyglucose) for characterization of ovarian tumor. Sassone score was used as sonomorphological scoring system to distinguish from malignant to benign lesion. This scoring system is based on ovarian inner wall structure, wall thickness, septation, and echogenicity. Serum CA-125 levels were measured. After surgery, based on histopathologic findings, sensitivity, specificity, accuracy of each diagnostic modality at each cut-off value were calculated. And the validity of three diagnostic modalities was analysed further with receiver operating characteristics (ROC) curve.

Results: In the sonographic evaluation of adnexal tumors, the sensitivity and specificity were 63% and 76% at the cut off level of 9 of Sassone score. With PET, both sensitivity and specificity was not improved respectively. The ROC curves show that PET does not provide statistically significant benefits to predict ovarian malignancy.

Conclusion: Our results suggested that CA-125 has no statistical significance and PET did not provide more significant additional diagnostic information than TVS for differentiation of malignant ovarian tumor from benign ovarian tumor.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sung Hoon(김성훈) ORCID logo https://orcid.org/0000-0002-1645-7473
Kim, Young Tae(김영태) ORCID logo https://orcid.org/0000-0002-7347-1052
Kim, Jae Wook(김재욱)
Kim, Jae Hoon(김재훈) ORCID logo https://orcid.org/0000-0001-6599-7065
Park, Yong Won(박용원)
Yun, Mi Jin(윤미진) ORCID logo https://orcid.org/0000-0002-1712-163X
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