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침윤성 자궁경부암에서 실시간 정량 역전사 중합효소 연쇄 반응을 이용한 cyclin B1과 D1의 발현

DC Field Value Language
dc.contributor.author강명화-
dc.contributor.author강명화-
dc.contributor.author김상운-
dc.contributor.author김성훈-
dc.contributor.author김영태-
dc.contributor.author김재욱-
dc.contributor.author김재훈-
dc.contributor.author윤보성-
dc.date.accessioned2017-10-26T06:45:55Z-
dc.date.available2017-10-26T06:45:55Z-
dc.date.issued2005-
dc.identifier.issn1738-6544-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/151264-
dc.description.abstractObjective : Cyclin is a family of regulatory proteins that play a key role in controlling the cell cycle. Abnormalities of cell cycle regulators, including cyclins and cyclin dependent kinases (CDKs), have been reported in malignant tumors. This study was undertaken to quantitatively detect cyclin B1 and D1 in cervical cancer. Methods : A quantitative real-time reverse transcriptase-polymerase chain reaction (RT-PCR) and Western blot analysis were used to analyze the expression of cyclin B1, D1 mRNA and proteins, respectively, in fresh invasive cervical cancer (n=41) and normal cervix tissue (n=10). Results : There was significantly greater cyclin B1 expression in invasive cervical cancer than in normal cervix tissue (p=0.019). However, cyclin D1 expression was not significantly different (p=0.967). A Western blot analysis yielded similar results. Conclusion : Our results were consistent with the concept that up-regulation of cyclin B1 expression occurred in cervical cancer and an aberrant expression of cyclin B1 might play an important role in cervical carcinogenesis.-
dc.description.statementOfResponsibilityrestriction-
dc.languageKorean-
dc.publisher대한부인종양,콜포스코피학회-
dc.relation.isPartOfKorean Journal of Gynecologic Oncology (부인종양)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHBlotting, Western-
dc.subject.MESHCervix Uteri/physiology-
dc.subject.MESHCyclin B/genetics*-
dc.subject.MESHCyclin B/metabolism-
dc.subject.MESHCyclin B1-
dc.subject.MESHCyclin D1/genetics*-
dc.subject.MESHCyclin D1/metabolism-
dc.subject.MESHDNA, Complementary/genetics-
dc.subject.MESHFemale-
dc.subject.MESHGene Expression Profiling*-
dc.subject.MESHHumans-
dc.subject.MESHNeoplasm Invasiveness-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHRNA, Neoplasm/genetics-
dc.subject.MESHReference Values-
dc.subject.MESHReverse Transcriptase Polymerase Chain Reaction-
dc.subject.MESHUterine Cervical Neoplasms/genetics*-
dc.subject.MESHUterine Cervical Neoplasms/pathology-
dc.title침윤성 자궁경부암에서 실시간 정량 역전사 중합효소 연쇄 반응을 이용한 cyclin B1과 D1의 발현-
dc.title.alternativeCyclin B1 and D1 expression in invasive cervical cancer-
dc.typeArticle-
dc.publisher.locationKorea-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentYonsei Biomedical Research Center (연세의생명연구원)-
dc.contributor.departmentDept. of Obstetrics and Gynecology (산부인과학교실)-
dc.contributor.departmentDept. of Obstetrics and Gynecology (산부인과학교실)-
dc.contributor.departmentDept. of Obstetrics and Gynecology (산부인과학교실)-
dc.contributor.departmentDept. of Obstetrics and Gynecology (산부인과학교실)-
dc.contributor.departmentDept. of Obstetrics and Gynecology (산부인과학교실)-
dc.contributor.departmentDept. of Obstetrics and Gynecology (산부인과학교실)-
dc.contributor.googleauthor김영태-
dc.contributor.googleauthor자오민-
dc.contributor.googleauthor김희연-
dc.contributor.googleauthor강명화-
dc.contributor.googleauthor김재욱-
dc.contributor.googleauthor김성훈-
dc.contributor.googleauthor김재훈-
dc.contributor.googleauthor김상운-
dc.contributor.googleauthor윤보성-
dc.identifier.doiOAK-2005-05473-
dc.contributor.localIdA00020-
dc.contributor.localIdA00020-
dc.contributor.localIdA00526-
dc.contributor.localIdA00595-
dc.contributor.localIdA00729-
dc.contributor.localIdA00866-
dc.contributor.localIdA00876-
dc.contributor.localIdA02554-
dc.relation.journalcodeJ02020-
dc.relation.journalsince2005~2010-
dc.relation.journalafter2011~ Journal of Gynecologic Oncology-
dc.identifier.pmid16614707-
dc.identifier.urlhttp://kiss.kstudy.com/journal/thesis_name.asp?tname=kiss2002&key=2465235-
dc.relation.journalbefore~2004 Korean Journal of Gynecologic Oncology and Colposcopy (대한부인종양,콜포스코피학회지)-
dc.subject.keywordcervical cancer-
dc.subject.keywordcyclin B1-
dc.subject.keywordcyclin D1-
dc.subject.keywordreal-time RT-PCR-
dc.subject.keywordWestern blot-
dc.contributor.alternativeNameKang, Myung Hwa-
dc.contributor.alternativeNameKang, Myung Hwa-
dc.contributor.alternativeNameKim, Sang Wun-
dc.contributor.alternativeNameKim, Sung Hoon-
dc.contributor.alternativeNameKim, Young Tae-
dc.contributor.alternativeNameKim, Jae Wook-
dc.contributor.alternativeNameKim, Jae Hoon-
dc.contributor.alternativeNameYoon, Bo Sung-
dc.contributor.affiliatedAuthor강명화-
dc.citation.volume16-
dc.citation.number3-
dc.citation.startPage256-
dc.citation.endPage263-
dc.identifier.bibliographicCitationKorean Journal of Gynecologic Oncology (부인종양), Vol.16(3) : 256-263, 2005-
dc.date.modified2017-05-04-
dc.identifier.rimsid43985-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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