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Vaginal fluid β-human chorionic gonadotropin level in the diagnosis of premature rupture of membranes

Authors
 Young-Han Kim  ;  Yong-Won Park  ;  Han-Sung Kwon  ;  Ja-Young Kwon  ;  Bok-Ja Kim 
Citation
 ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, Vol.84(8) : 802-805, 2005 
Journal Title
 ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA 
ISSN
 0001-6349 
Issue Date
2005
MeSH
Adult ; Biomarkers/analysis ; Body Fluids ; Chorionic Gonadotropin, beta Subunit, Human/analysis ; Chorionic Gonadotropin, beta Subunit, Human/metabolism* ; Female ; Fetal Membranes, Premature Rupture/diagnosis* ; Follow-Up Studies ; Humans ; Maternal Age ; Parity ; Predictive Value of Tests ; Pregnancy ; Pregnancy Outcome* ; Pregnancy Trimester, Second ; Pregnancy Trimester, Third ; Prospective Studies ; Sensitivity and Specificity ; Vagina/chemistry*
Keywords
premature rupture of membranes (PROM) ; vaginal β‐HCG
Abstract
Background.  To determine whether the measurement of β-human chorionic gonadotropin (β-HCG) level in the vaginal washing fluid could be useful for the diagnosis of premature rupture of membranes. Methods.  Totally, 120 pregnant women were enrolled in this study. Subjects were divided into four groups [group I, no preterm labor and term delivery (n = 38); group II, preterm labor and term delivery (n = 12); group III, preterm labor and consequent premature delivery (n = 24); group IV, preterm labor with premature rupture of membranes (PROM) and consequent premature delivery (n = 46)]. After irrigating the posterior vaginal fornix with 3 ml of sterile saline and the obtained vaginal washing fluid, we measured β-HCG levels. Results.  The median and range of vaginal fluid β-HCG levels were 3.60 (0.09–30.52), 4.42 (0.33–10.02), 15.50 (0.25–378.62), and 512.53 (26.95–3507.20) mIU/ml in group I, group II, group III, and group IV, respectively. Vaginal β-HCG level was significantly higher in patients with PROM followed by premature delivery (group IV) than patients in other groups (P < 0.01). From the receiver operating characteristic curve, 39.8mIU/ml was set as a cutoff value. Sensitivity, specificity, positive predictive value, and negative predictive value were 95.5, 94.7, 91.3, and 97.3%, respectively. Conclusion.  Our study demonstrated that the measurement of vaginal fluid β-HCG may be reliable, simple, and rapid test in diagnosing PROM and used as a adjunctive test in equivocal cases.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.0001-6349.2005.00712.x/abstract
DOI
10.1111/j.0001-6349.2005.00712.x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Ja Young(권자영) ORCID logo https://orcid.org/0000-0003-3009-6325
Kim, Young Han(김영한) ORCID logo https://orcid.org/0000-0003-0645-6028
Park, Yong Won(박용원)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/151259
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