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고인슐린혈증에 의해 유발된 저칼륨혈증 주기성 마비 1예

Other Titles
 A case of hypokalemic perodic paralysis induced by hyperinsulinemia 
Authors
 장진혁  ;  김철식  ;  박종관  ;  박진아  ;  조민호  ;  안철우  ;  김경래 
Citation
 Korean Journal of Medicine (대한내과학회지), Vol.68(6) : 692-696, 2005 
Journal Title
 Korean Journal of Medicine (대한내과학회지) 
ISSN
 1226-329X 
Issue Date
2005
MeSH
Paralysis ; Hypokalemic Periodic ; Hyperinsulinemia
Keywords
Paralysis ; Hypokalemic Periodic ; Hyperinsulinemia
Abstract
Hypokalemia periodic paralysis, a clinical syndrome characterised by systemic weakness and low serum potassium, is a rare but treatable cause of acute weakness. Attacks of flaccid paralysis can be associated with hypokalemia triggered by insulin. Insulin reduce the conductance of the inward rectifier K+ channel for outward-flowing currents. Therefore, insulin potentiates depolarization of hypokalmeic periodic paralysis. We have experienced a case of hypokalemic periodic paralysis induced by hyperinsulinemia in 38-year old man, with complaint of intermittent paralysis of extremities. On admission, serum K+ was 2.1 mEq/L. He was no family history of muscle weakness. Thyroid function was normal. Serum levels of aldosterone, renin and cortisol were normal. Random plasma glucose level was 129 mg/dL and serum insulin was 131 uIU/mL. Shortly after intravenous supplementation of potassium, muscle weakness was improved. Oral glucose tolerance test revealed impaired glucose tolerance and hyperresponse of insulin and phosphate.
Files in This Item:
T200501159.pdf Download
DOI
OAK-2005-05595
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Rae(김경래)
Kim, Chul Sik(김철식)
Park, Jina(박진아)
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/151253
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