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Matrix Metalloproteinases(MMPs) 및 Vascular Endothelial Growth Factor(VEGF)의 발현을 통한 구강 설암의 침윤 기전 연구

Other Titles
 Correlations of Oral Tongue Cancer Invasion with Matrix Metalloproteinases(MMPs) and Vascular Endothelial Growth Factor(VEGF) Expression 
Authors
 김세헌  ;  조남훈  ;  임재열  ;  김지훈  ;  김정홍  ;  장정현  ;  최은창 
Citation
 Korean Journal of Head & Neck Oncology (대한두경부종양학회지), Vol.21(1) : 3-9, 2005 
Journal Title
 Korean Journal of Head & Neck Oncology (대한두경부종양학회지) 
ISSN
 1229-5183 
Issue Date
2005
MeSH
Adult ; Aged ; Biomarkers, Tumor/metabolism ; Female ; Humans ; Immunohistochemistry ; Lymph Nodes/pathology ; Lymphatic Metastasis ; Male ; Matrix Metalloproteinase 2/metabolism ; Matrix Metalloproteinase 9/metabolism ; Matrix Metalloproteinases/metabolism* ; Middle Aged ; Neoplasm Invasiveness ; Neoplasm Staging ; Neovascularization, Pathologic/pathology ; Platelet Endothelial Cell Adhesion Molecule-1/metabolism ; Prognosis ; Survival Rate ; Tongue Neoplasms/blood supply ; Tongue Neoplasms/metabolism* ; Tongue Neoplasms/mortality ; Tongue Neoplasms/pathology* ; Vascular Endothelial Growth Factor A/metabolism*
Keywords
tongue cancer ; tumor depth ; VEGF ; MMPs
Abstract
Purpose: In oral tongue cancer, the degree of tumor invasion has a significant effect on the prognosis. We hypothesized that the destruction of extracelluar matrix and neovascularization are related to tumor infiltration mechanism. By studying the the tissues of early stage oral tongue cancer patients, we are intend to clarify the invasion related factors in oral tongue cancer. Material and Methods: To demonstrate the invasion process in early T-stage oral tongue cancer, the expressions of extracellular matrix destruction related molecules(MMP2, MMP9) and neovascularization related molecule(VEGF) were observed by immunohistochemical study. Also, immunohistochemical staining of CD31 was done for quantification of neovascularization. With the experiment showed above, we analyzed relationship between expression of each substances and tumor invasion depth, tumor free survival rates and cervical lymph node metastasis rate in early T-stage oral tongue cancer. Results: The expression rates of MMP2, MMP9, VEGF in 38 early oral cancer patients were 52.6%, 78.9% 52.6%, respectively. Significant correlation was found between the VEGF expression and microvessel density showed by CD31 immunohistochemical staining(p<0.001). VEGF expressions were significantly related with tumor invasion depth(p=0.002). The tumor free survival rate of those patients with VEGF-positive tumors was significantly poorer than in those with VEGF-negative tumors(p=0.019). Conclusion: This results indicate that VEGF is a useful marker for predicting the tumor invasion in patients with early tongue cancer and could be used as a beneficial factors in defining operative field and prognosis.
Files in This Item:
T200501053.pdf Download
DOI
10.1002/jso.20461
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Se Heon(김세헌)
Kim, Jeong Hong(김정홍)
Cho, Nam Hoon(조남훈) ORCID logo https://orcid.org/0000-0002-0045-6441
Choi, Eun Chang(최은창)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/151218
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