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제2형 당뇨병 환자에서 apo E 및 ACE 유전자 다형성이 당뇨병성 신증에 미치는 영향

Other Titles
 Apolipoprotein E and ACE genetic polymorphism and nephropathy in type 2 diabetic patients 
 박종숙  ;  남주영  ;  김철식  ;  김똘미  ;  조민호  ;  박진아  ;  안철우  ;  차봉수  ;  임승길  ;  김경래  ;  이현철 
 Korean Journal of Medicine (대한내과학회지), Vol.68(5) : 511-518, 2005 
Journal Title
 Korean Journal of Medicine (대한내과학회지) 
Issue Date
Background : The aim of this study was to investigate the association between apo E and ACE genetic polymorphism and diabetic nephropathy. Methods : One hundred eighteen patients with type 2 diabetes who had a duration of diabetes longer than 8 years were divided into the three apo E groups (E2, E3, E4) and three ACE groups (II, ID, DD). Plasma levels of lipids were measured. The frequency of diabetic nephropathy and clinical and biochemical characteristics were compared among the Apo E and ACE genotype groups. Results : The frequency of overt nephropathy was significantly greater in apo E2 patients with diabetes (46.7%) than apo E3 (16.7%) or apo E4 patients (10.5%). Logistical regression analysis showed that odds ratio of apo E2 and apo E4 genotypes for the presence of overt nephropathy were 4.779 (p<0.01) and 0.643 (p=0.583), respectively. Plasma TG levels were significantly greater in apo E2 patients. This study did not show an association between ACE gene polymorphism and diabetic nephropathy, and no interaction between Apo E and ACE gene polymorphism. Conclusion : Apo E2 is a prognostic risk factor for diabetic nephropathy in Korean type 2 diabetes. TG may have an important role of diabetic nephropathy. There were not synergistic effect between Apo E and ACE gene polymorphism in diabetic nephropathy
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
김경래(Kim, Kyung Rae)
김똘미(Kim, Dol Mi)
김철식(Kim, Chul Sik)
남주영(Nam, Ju Young)
박종숙(Park, Jong Suk) ORCID logo https://orcid.org/0000-0002-5385-1373
박진아(Park, Jina)
안철우(Ahn, Chul Woo)
이현철(Lee, Hyun Chul)
임승길(Lim, Sung Kil)
차봉수(Cha, Bong Soo) ORCID logo https://orcid.org/0000-0003-0542-2854
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