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비당뇨병성인에서 LDL 입자크기와 내중막 두께 및 인슐린저항성과의 연관성

Other Titles
 Relationship of LDL Particle Size to IMT and Insulin Resistance in Non-Diabetic Adult 
 박진아  ;  김철식  ;  박종숙  ;  김똘미  ;  조민호  ;  공지현  ;  김혜진  ;  김정호  ;  안철우  ;  차봉수  ;  임승길  ;  김경래  ;  이현철 
 Journal of Korean Diabetes Association (당뇨병), Vol.29(4) : 333-343, 2005 
Journal Title
 Journal of Korean Diabetes Association (당뇨병) 
Issue Date
LDL subfraction ; Insulin resistance ; Carotid intima-media thickness (IMT)
LDL subfraction ; Insulin resistance ; Carotid intima-media thickness (IMT)
Background: The aims of this study were to investigate the predictor of the low density lipoprotein(LDL) particle size and the relationship of the LDL particle size to the levels of insulin resistance and the carotid intima-media thickness (IMT) in healthy Koreans. Methods: The subjects were 47 and 89 clinically healthy males and females, aged between 32 and 70years, without medications that could potentially alter glucose and lipid metabolisms. The mean LDL particle size was determined by polyacrylamide tube gel electrophoresis(LipoprintⓇ LDL, Quantimetrix), the insulin resistance using a short insulin tolerance test kit, and the subclinical atherosclerosis from the carotid intima-media thickness. Results: The LDL particle size was found to be significantly correlated with insulin resistance using a simple Pearson’s correlation(r=0.233, P<0.01), but the independent predictors of the LDL particle size, as determined by a multiple stepwise regression analysis, were serum triglyceride(TG), high density lipoprotein(HDL) cholesterol level and age(beta=-0.403, P=< 0.001; beta=0.309, P=0.003; beta=-0.219, P=0.016, respectively). Significant relationships were found between an increasing IMT and the traditional risk factors of atherosclerosis: age, LDL cholesterol, HDL cholesterol, systolic and diastolic blood pressure(r=0.490, P<0.001; r=-0.251, P<0.01; r=0.211, P<0.05; r=0.298, P<0.01; r=0.263, P<0.01, respectively). However, no significant correlation was found between an increasing IMT and the LDL particle size (r=-0.172, P=0.075). Conclusion: The best predictors for the LDL particle size were the serum TG level, HDL cholesterol level and age. Insulin resistance was not found to be an independent predictor of the LDL particle size. Small dense LDL was not found to be a predictor of the IMT in healthy Koreans.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Rae(김경래)
Kim, Dol Mi(김똘미)
Kim, Jeong Ho(김정호) ORCID logo https://orcid.org/0000-0003-2479-0548
Kim, Chul Sik(김철식)
Park, Jong Suk(박종숙) ORCID logo https://orcid.org/0000-0002-5385-1373
Park, Jina(박진아)
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Lee, Hyun Chul(이현철)
Lim, Sung Kil(임승길)
Cha, Bong Soo(차봉수) ORCID logo https://orcid.org/0000-0003-0542-2854
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