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Spatio-Temporal Expression Pattern of Grp78, a Putative Hoxc8 Downstream Target Gene, During Murine Embryogenesis

DC Field Value Language
dc.contributor.author권윤정-
dc.contributor.author김명희-
dc.contributor.author김명희-
dc.contributor.author박형우-
dc.contributor.author양혜원-
dc.date.accessioned2017-10-26T06:42:31Z-
dc.date.available2017-10-26T06:42:31Z-
dc.date.issued2005-
dc.identifier.issn1738-3226-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/151200-
dc.description.abstractGrp78, discovered as one of the putative target genes of Hoxc8, is a highly conserved stress protein and functions as a molecular chaperone in the endoplasmic reticulum (ER). In order to see the stage-specific expression pattern of Grp78 during development, mouse embryos from day 7.5 to 17.5 p.c. were isolated, and RT-PCR as well as in situ hybridization was performed. When RT-PCR was performed using Grp78 specific primers, periodic expression pattern was detected. And also a region-specific expression pattern was detected with a strong expression in the trunk part of day 11.5 p.c. embryo, like that of Hoxc8. When in situ hybridization was performed, Grp78 was revealed to be expressed in the endoderm, somite, neuroepitheliurm cells of neural tube in early embryos. In the case of late embryos, Grp78 expression was detected in the liver, segmental bronchus within cranial lobe of lung, ossification center within the cartilage primordium of rib and vertebra, submandibular gland, as well as metanephros. These expression Patterns are very much similar to those of Hoxc8. Since Hoxc8 has been reported to regulate apoptosis during organogenesis, it might be possible that the apoptotic function could have been conveyed through the expression of Grp78, implying that the Grp78 is one of the Hoxc8 downstream target genes.-
dc.description.statementOfResponsibilityopen-
dc.languageKorean, English-
dc.publisherKorean Society For Biomedical Laboratory Sciences-
dc.relation.isPartOfJournal of Experimental & Biomedcal Science (대한의생명과학회지)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHExpression pattern-
dc.subject.MESHEmbryogenesis-
dc.subject.MESHGrp78-
dc.titleSpatio-Temporal Expression Pattern of Grp78, a Putative Hoxc8 Downstream Target Gene, During Murine Embryogenesis-
dc.typeArticle-
dc.publisher.locationKorea-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Anatomy (해부학교실)-
dc.contributor.departmentDept. of Anatomy (해부학교실)-
dc.contributor.departmentDept. of Anatomy (해부학교실)-
dc.contributor.departmentDept. of Anatomy (해부학교실)-
dc.contributor.departmentDept. of Anatomy (해부학교실)-
dc.contributor.googleauthorJin Joo Kang-
dc.contributor.googleauthorYunjeong Kwon-
dc.contributor.googleauthorEun Young Lee-
dc.contributor.googleauthorHyoung Woo Park-
dc.contributor.googleauthorHye-Won Yang-
dc.contributor.googleauthorMyoung Hee Kim-
dc.identifier.doiOAK-2005-05375-
dc.contributor.localIdA00241-
dc.contributor.localIdA00432-
dc.contributor.localIdA00432-
dc.contributor.localIdA01756-
dc.contributor.localIdA02326-
dc.relation.journalcodeJ01408-
dc.relation.journalsince2004~-
dc.relation.journalbefore~2004 Journal of Biomedical Laboratory Sciences (대한의생명과학회지)-
dc.subject.keywordExpression pattern-
dc.subject.keywordEmbryogenesis-
dc.subject.keywordGrp78-
dc.contributor.alternativeNameKwon, Yunjeong-
dc.contributor.alternativeNameKim, Myoung Hee-
dc.contributor.alternativeNameKim, Myoung Hee-
dc.contributor.alternativeNamePark, Hyoung Woo-
dc.contributor.alternativeNameYang, Hye Won-
dc.citation.volume11-
dc.citation.number3-
dc.citation.startPage311-
dc.citation.endPage318-
dc.identifier.bibliographicCitationJournal of Experimental & Biomedcal Science (대한의생명과학회지), Vol.11(3) : 311-318, 2005-
dc.date.modified2017-05-04-
dc.identifier.rimsid43924-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers

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