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Limitation of the validity of the homeostasis model assessment as an index of insulin resistance in Korea

 Eun Seok Kang  ;  Yong Seok Yun  ;  Seok Won Park  ;  Hyeung Jin Kim  ;  Chul Woo Ahn  ;  Young Duk Song  ;  Bong Soo Cha  ;  Sung Kil Lim  ;  Kyung Rae Kim  ;  Hyun Chul Lee 
 Metabolism: Clinical and Experimental, Vol.54(2) : 206-211, 2005 
Journal Title
 Metabolism: Clinical and Experimental 
Issue Date
Homeostasis model assessment of insulin resistance (HOMA-IR) is a less invasive, inexpensive, and less labor-intensive method to measure insulin resistance (IR) as compared with the glucose clamp test. The aim of this study was to evaluate the validity of HOMA-IR by comparing it with the euglycemic clamp test in determining IR. We assessed the validity of HOMA-IR by comparing it with the total glucose disposal rate measured by the 3-hour euglycemic-hyperinsulinemic clamp in subjects with type 2 diabetes (n = 47), impaired glucose tolerance (n = 21), and normal glucose tolerance (n = 22). There was a strong inverse correlation (r = −0.558; P < .001) between the log-transformed HOMA-IR and the total glucose disposal rate. There was moderate agreement between the 2 methods in the categorization according to the IR (weighted κ = 0.294). The magnitude of the correlation coefficients was smaller in the subjects with a lower body mass index (BMI <25.0 kg/m2, r = −0.441 vs BMI ≥25.0 kg/m2, r = −0.615; P = .032), a lower HOMA-beta cell function (HOMA-β <60.0, r = −0.527 vs HOMA-β ≥60.0, r = −0.686; P = .016), and higher fasting glucose levels (fasting glucose ≤5.66 mmol/L, r = −0.556 vs fasting glucose >5.66 mmol/L, r = −0.520; P = .039). The limitation of the validity of the HOMA-IR should be carefully considered in subjects with a lower BMI, a lower beta cell function, and high fasting glucose levels such as lean type 2 diabetes mellitus with insulin secretory defects.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Eun Seok(강은석) ORCID logo https://orcid.org/0000-0002-0364-4675
Kim, Kyung Rae(김경래)
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Yun, Yong Seok(윤용석)
Lee, Hyun Chul(이현철)
Lim, Sung Kil(임승길)
Cha, Bong Soo(차봉수) ORCID logo https://orcid.org/0000-0003-0542-2854
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