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OLETF 쥐에서 Lithospermate B의 당뇨병성신증에 대한 보호 효과

Other Titles
 Protective Effects of Lithospermate B on Diabetic Nephropathy in OLETF Rat 
Authors
 이현주  ;  이근택  ;  강은석  ;  허규연  ;  조정산  ;  안철우  ;  하헌주  ;  정만길  ;  차봉수  ;  이현철 
Citation
 Journal of Korean Diabetes Association (당뇨병), Vol.29(4) : 322-332, 2005 
Journal Title
 Journal of Korean Diabetes Association (당뇨병) 
ISSN
 1015-6461 
Issue Date
2005
Abstract
Background: Magnesium lithospermate B(LAB), an active component isolated from Salvia milltiorrhizae, has been reported to have renoprotective effects in type 1 diabetic animal model. The purpose of this study was to examine the effects of LAB on the prevention of diabetic nephropathy in Otsuka Long-Evans Tokushima Fatty(OLETF) rat which is regarded as an animal model of type 2 diabetes. Methods: Ten microgram of LAB/kg or Vehicle(PBS) was given orally once daily to 10-week-old male OLETF rats and LETO rats for 40 weeks. Intra-peritoneal glucose tolerance test was performed at 50 weeks. 24 hr urinary protein excretion amounts were measured. Lipid peroxidation, TGF-beta1 and ED-1 of renal cortex were measured. Results: The mean body weight of LAB+OLETF was not significantly different from that of OLETF rats. LAB treatment decreased proteinuria, lipid peroxidation, and free fatty acid in OLETF rats without decrease in the plasma glucose concentration. Also, LAB inhibited the progression of glomerular hypertrophy and mesangial expansion. LAB effectively decreased ED-1 positive cells, ECM expansion, and TGF-beta1 level in the renal cortex of OLETF rats. Conclusion: These results suggest that the beneficial effects of LAB on the diabetic renal damage in the OLETF rats may depend on a mechanism of decreasing oxidative stress. LAB might be a new therapeutic agent for the prevention of nephropathy in type 2 diabetes as well as type 1 diabetes.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
강은석(Kang, Eun Seok) ORCID logo https://orcid.org/0000-0002-0364-4675
안철우(Ahn, Chul Woo) ORCID logo https://orcid.org/0000-0003-3733-7486
이현주(Lee, Hyun Joo)
이현철(Lee, Hyun Chul)
차봉수(Cha, Bong Soo) ORCID logo https://orcid.org/0000-0003-0542-2854
허규연(Hur, Kyu Yeon)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/151130
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