Cited 13 times in
Pharmacokinetic changes of DA-7867, a new oxazolidinone, after intravenous and oral administration to rats with short-term and long-term diabetes mellitus induced by streptozotocin
DC Field | Value | Language |
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dc.contributor.author | 이덕철 | - |
dc.date.accessioned | 2017-10-26T06:38:19Z | - |
dc.date.available | 2017-10-26T06:38:19Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 0928-0987 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/151112 | - |
dc.description.abstract | Effects of diabetes mellitus induced by streptozotocin (DMIS) on the pharmacokinetics of DA-7867 were investigated after i.v. and oral administration (10 mg/kg) to control Sprague–Dawley rats and DMIS rats (at 7th and 29th days after administration of streptozotocin, 45 mg/kg). After i.v. administration to DMIS rats, the AUC0–∞ values were significantly smaller (50.7 and 64.8% decrease for 7th and 29th days, respectively); this could be due to significantly faster Cl values in the rats (127 and 183% increase for 7th and 29th days, respectively). The faster Cl values were mainly due to significantly greater amount of unchanged drug excreted in 24-h urine (Ae0–24 h). The greater Ae0–24 h in DMIS rats could be due to urine flow rate-dependent renal clearance of DA-7867. After oral administration to DMIS rats, the AUC0–∞ values were also significantly smaller (61.3 and 72.6% decrease for 7th and 29th days, respectively); this could also be mainly due to significantly greater Ae0–24 h in the rats. Streptozotocin-induced hepatotoxicity did not influence considerably on the pharmacokinetics of DA-7867 at 7th day when compared with those at 29th day. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier Science B.V | - |
dc.relation.isPartOf | EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Administration, Oral | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Area Under Curve | - |
dc.subject.MESH | Diabetes Mellitus, Experimental/metabolism* | - |
dc.subject.MESH | Injections, Intravenous | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Metabolic Clearance Rate | - |
dc.subject.MESH | Oxazolidinones/administration & dosage | - |
dc.subject.MESH | Oxazolidinones/pharmacokinetics* | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Streptozocin | - |
dc.subject.MESH | Time Factors | - |
dc.title | Pharmacokinetic changes of DA-7867, a new oxazolidinone, after intravenous and oral administration to rats with short-term and long-term diabetes mellitus induced by streptozotocin | - |
dc.type | Article | - |
dc.publisher.location | Netherlands | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Family Medicine (가정의학교실) | - |
dc.contributor.googleauthor | Soo K. Bae | - |
dc.contributor.googleauthor | Si H. Yang | - |
dc.contributor.googleauthor | Shin J. Lee | - |
dc.contributor.googleauthor | Jong W. Kwon | - |
dc.contributor.googleauthor | Won B. Kim | - |
dc.contributor.googleauthor | Duk C. Lee | - |
dc.contributor.googleauthor | Myung G. Lee | - |
dc.identifier.doi | 10.1016/j.ejps.2005.03.009 | - |
dc.contributor.localId | A02716 | - |
dc.relation.journalcode | J00840 | - |
dc.identifier.eissn | 1879-0720 | - |
dc.identifier.pmid | 15911231 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0928098705001041 | - |
dc.subject.keyword | DA-7867 | - |
dc.subject.keyword | Diabetes mellitus | - |
dc.subject.keyword | Streptozotocin | - |
dc.subject.keyword | Pharmacokinetics | - |
dc.subject.keyword | Rats | - |
dc.contributor.alternativeName | Lee, Duk Chul | - |
dc.citation.volume | 25 | - |
dc.citation.number | 2~3 | - |
dc.citation.startPage | 337 | - |
dc.citation.endPage | 345 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, Vol.25(2~3) : 337-345, 2005 | - |
dc.date.modified | 2017-05-04 | - |
dc.identifier.rimsid | 43454 | - |
dc.type.rims | ART | - |
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