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치료방법이 미분화 갑상선암의 생존 기간에 미치는 효과

Other Titles
 The Effect of Treatment Modalities on Survival Rates of Patients with?Anaplastic Thyroid Carcinoma 
Authors
 Jae Myoung Choi  ;  Mi Jeong Kim  ;  Seung Won Lee  ;  Kyoung Eun Song  ;  Yoon-Sok Chung  ;  Kwan Woo Lee  ;  Dae Jung Kim  ;  Sung Hee Choi  ;  So Hun Kim  ;  Min Ho Cho  ;  Yumie Rhee  ;  Chul Woo Ahn  ;  Sung Kil Lim  ;  Kyung Rae Kim 
Citation
 Endocrinology and Metabolism (대한내분비학회지), Vol.20(2) : 127-133, 2005 
Journal Title
Endocrinology and Metabolism(대한내분비학회지)
ISSN
 2093-596X 
Issue Date
2005
MeSH
Anaplastic thyroid carcinoma ; Surgery ; Treatment modalities ; Treatment outcome
Keywords
Anaplastic thyroid carcinoma ; Surgery ; Treatment modalities ; Treatment outcome
Abstract
Background : Anaplastic thyroid carcinoma represents 2% to 5% of all thyroid cancers and it is one of the most aggressive human cancers. Local extension at the time of diagnosis and distant metastases are almost always the rule. Its lethality is evidenced by a 5-year survival rate of 3.6% and a median survival time of 4 months. We retrospectively reviewed patients with this disease at 4 tertiary referral centers.
Methods : From 1990 to 2003, 19 cases (9 men and 10 women, mean age: 65.1 ± 7.1 years) of anaplastic thyroid carcinoma were reviewed via the medical records. The overall survival rates according to the prognostic factors and the treatment modalities were analyzed.
Results : The presenting symptoms included rapidly enlarged neck masses in 16 patients, shortness of breath in 3 patients, hoarseness in 4 patients, dysphagia in 2 patients and chest wall pain in 1 patient. The mean diameter of tumor was 7.2 cm. Local extension was seen in all of the cases that had undergone surgery. Distant metastases (lung 6, bone 2, abdominal carcinomatosis 2, brain 1 and mediastinum 1) were seen in 9 patients. Surgical treatment was performed in 10 patients. Radiotherapy was performed in 9 patients and chemotherapy was done in 5 patients; radiotherapy was performed alone in 2 patients, combination chemo-radiotherapy was performed in 3 patients, postoperative radiotherapy was performed in 2 patients and postoperative combination chemo-radiotherapy was performed in 2 patients. 4 patients were treated cons ervatively after the confirmative diagnosis. The overall median survival time was 123 days (range: 23~621 days); the median survival time was 129 days in the treatment group (n=15), and 27 days in the no treatment group (n=4), and significantly higher survival rates were observed for the treated patients (p=0.02). According to the treatment modalities, patients who underwent surgical treatment and postoperative radiotherapy and/or chemotherapy were observed to have significantly higher survival rates than patients in the radiotherapy and/or chemotherapy group (p=0.03), and also than those patients in the surgical treatment only group (p=0.04).
Conclusion : We found that aggressive surgical treatment and postoperative radiotherapy and/or chemotherapy improved the survival rates of patients with anaplastic thyroid carcinoma even though local invasion and distant metastases was generally observed to occur.
Files in This Item:
T200500942.pdf Download
DOI
10.3803/jkes.2005.20.2.127
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Rae(김경래)
Kim, So Hun(김소헌)
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Rhee, Yumie(이유미) ORCID logo https://orcid.org/0000-0003-4227-5638
Lim, Sung Kil(임승길)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/151107
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