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Role of neuropeptide Y and proopiomelanocortin in fluoxetine-induced anorexia

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dc.contributor.author장정원-
dc.date.accessioned2017-10-26T06:37:41Z-
dc.date.available2017-10-26T06:37:41Z-
dc.date.issued2005-
dc.identifier.issn0253-6269-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/151097-
dc.description.abstractFluoxetine is an anorexic agent known to reduce food intake and weight gain. However, the molecular mechanism by which fluoxetine induces anorexia has not been well-established. We examined mRNA expression levels of neuropeptide Y (NPY) and proopiomelanocortin (POMC) in the brain regions of rats using RT-PCR andin situ hybridization techniques after 2 weeks of administering fluoxetine daily. Fluoxetine persistently suppressed food intake and weight gain during the experimental period. The pair-fed group confirmed that the reduction in body weight in the fluoxetine treated rats resulted primarily from decreased food intake. RT-PCR analyses showed that mRNA expression levels of both NPY and POMC were markedly reduced by fluoxetine treatment in all parts of the brain examined, including the hypothalamus. POMC mRNAin situ signals were significantly decreased, NPY levels tended to increase in the arcuate nucleus (ARC) of fluoxetine treated rats (compared to the vehicle controls). In the pair-fed group, NPY mRNA levels did not change, but the POMC levels decreased (compared with the vehicle controls). These results reveal that the chronic administration of fluoxetine decreases expression levles in both NPY and POMC in the brain, and suggests that fluoxetine-induced anorexia may not be mediated by changes in the ARC expression of either NPY or POMC. It is possible that a fluoxetine raised level of 5-HT play an inhibitory role in the orectic action caused by a reduced expression of ARC POMC (α-MSH).-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherPharmaceutical Society of Korea-
dc.relation.isPartOfARCHIVES OF PHARMACAL RESEARCH-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHAnorexia/chemically induced-
dc.subject.MESHAnorexia/metabolism*-
dc.subject.MESHAppetite Regulation/drug effects*-
dc.subject.MESHArcuate Nucleus of Hypothalamus/chemistry-
dc.subject.MESHArcuate Nucleus of Hypothalamus/metabolism*-
dc.subject.MESHAutoradiography-
dc.subject.MESHBody Weight/drug effects-
dc.subject.MESHBrain Chemistry/drug effects-
dc.subject.MESHEating/drug effects-
dc.subject.MESHFluoxetine*-
dc.subject.MESHGene Expression Regulation/drug effects-
dc.subject.MESHMale-
dc.subject.MESHNeuropeptide Y/biosynthesis-
dc.subject.MESHNeuropeptide Y/metabolism*-
dc.subject.MESHPro-Opiomelanocortin/biosynthesis-
dc.subject.MESHPro-Opiomelanocortin/metabolism*-
dc.subject.MESHRNA/isolation & purification-
dc.subject.MESHRNA, Messenger/metabolism-
dc.subject.MESHRats-
dc.subject.MESHRats, Sprague-Dawley-
dc.subject.MESHReverse Transcriptase Polymerase Chain Reaction-
dc.subject.MESHSerotonin Uptake Inhibitors*-
dc.titleRole of neuropeptide Y and proopiomelanocortin in fluoxetine-induced anorexia-
dc.typeArticle-
dc.publisher.locationKorea-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pharmacology (약리학교실)-
dc.contributor.googleauthorChang-Seon Myung-
dc.contributor.googleauthorBom-Taeck Kim-
dc.contributor.googleauthorSi Ho Choi-
dc.contributor.googleauthorGyu Yong Song-
dc.contributor.googleauthorSeok Yong Lee-
dc.contributor.googleauthorJeong Won Jahng-
dc.identifier.doiOAK-2005-04809-
dc.contributor.localIdA03467-
dc.relation.journalcodeJ00229-
dc.identifier.pmid16042082-
dc.identifier.urlhttp://link.springer.com/article/10.1007%2FBF02969363-
dc.subject.keywordFluoxetine-
dc.subject.keywordNeuropeptide Y-
dc.subject.keywordProopiomelanocortin-
dc.subject.keywordHypothalamus-
dc.subject.keywordRats-
dc.subject.keywordAnorexia-
dc.contributor.alternativeNameJahng, Jeong Won-
dc.citation.volume28-
dc.citation.number6-
dc.citation.startPage716-
dc.citation.endPage721-
dc.identifier.bibliographicCitationARCHIVES OF PHARMACAL RESEARCH, Vol.28(6) : 716-721, 2005-
dc.date.modified2017-05-04-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers

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