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Pharmacokinetics of theophylline in diabetes mellitus rats: Induction of CYP1A2 and CYP2E1 on 1,3-dimethyluric acid formation

DC FieldValueLanguage
dc.contributor.author이덕철-
dc.date.accessioned2017-10-26T06:37:20Z-
dc.date.available2017-10-26T06:37:20Z-
dc.date.issued2005-
dc.identifier.issn0928-0987-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/151090-
dc.description.abstractPharmacokinetic parameters of theophylline and one of its metabolites, 1,3-dimethyluric acid (1,3-DMU), were compared after intravenous and oral administration of aminophylline, 5 mg/kg as theophylline, to diabetes mellitus rats induced by alloxan (DMIA) or streptozotocin (DMIS), and their respective control rats. In DMIA and DMIS rats, expression of CYP1A2 and 2E1 increased approximately three times. Theophylline was metabolized to 1,3-DMU by CYP1A2 and 2E1 in rats. Hence, it was expected that formation of 1,3-DMU increased in DMIA or DMIS rats. This was proven by the following results. First, after intravenous administration of theophylline, the AUC of 1,3-DMU was significantly greater in DMIA (110% increase) or DMIS (47.4% increase) rats. Second, the AUC of theophylline was significantly smaller in DMIA (26.1% decrease) or DMIS (30.1% decrease) rats because of significantly faster time-averaged total body clearance in DMIA (34.8% increase) or DMIS (42.7% increase) rats. Third, based on in vitro hepatic microsomal studies, intrinsic 1,3-DMU formation clearances were significantly faster in DMIA (20.4% increase) or DMIS (30.7% increase) rats than respective control rats. Similar results (AUC values of theophylline and 1,3-DMU) were also obtained after oral administration.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier Science B.V-
dc.relation.isPartOfEUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdministration, Oral-
dc.subject.MESHAlloxan-
dc.subject.MESHAminophylline/administration & dosage-
dc.subject.MESHAminophylline/pharmacokinetics-
dc.subject.MESHAnimals-
dc.subject.MESHCytochrome P-450 CYP1A2/biosynthesis*-
dc.subject.MESHCytochrome P-450 CYP1A2/genetics-
dc.subject.MESHCytochrome P-450 CYP2E1/biosynthesis*-
dc.subject.MESHCytochrome P-450 CYP2E1/genetics-
dc.subject.MESHDiabetes Mellitus, Experimental/chemically induced-
dc.subject.MESHDiabetes Mellitus, Experimental/metabolism*-
dc.subject.MESHEnzyme Induction-
dc.subject.MESHInjections, Intravenous-
dc.subject.MESHMale-
dc.subject.MESHRNA, Messenger/analysis-
dc.subject.MESHRats-
dc.subject.MESHRats, Sprague-Dawley-
dc.subject.MESHStreptozocin-
dc.subject.MESHTheophylline/blood-
dc.subject.MESHTheophylline/pharmacokinetics*-
dc.subject.MESHUric Acid/analogs & derivatives*-
dc.subject.MESHUric Acid/blood-
dc.subject.MESHUric Acid/pharmacokinetics-
dc.titlePharmacokinetics of theophylline in diabetes mellitus rats: Induction of CYP1A2 and CYP2E1 on 1,3-dimethyluric acid formation-
dc.typeArticle-
dc.publisher.locationNetherlands-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Family Medicine (가정의학교실)-
dc.contributor.googleauthorYu Chul Kim-
dc.contributor.googleauthorAe Kyung Lee-
dc.contributor.googleauthorJoo Hyun Lee-
dc.contributor.googleauthorInchul Lee-
dc.contributor.googleauthorDuk Chul Lee-
dc.contributor.googleauthorSo Hee Kim-
dc.contributor.googleauthorSang Geon Kim-
dc.contributor.googleauthorMyung Gull Lee-
dc.identifier.doi10.1016/j.ejps.2005.05.004-
dc.contributor.localIdA02716-
dc.relation.journalcodeJ00840-
dc.identifier.eissn1879-0720-
dc.identifier.pmid15985363-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0928098705001703-
dc.subject.keywordTheophylline-
dc.subject.keyword1,3-DMU-
dc.subject.keywordCYP1A2-
dc.subject.keywordCYP2E1-
dc.subject.keywordPharmacokinetics-
dc.subject.keywordDiabetes mellitus-
dc.subject.keywordAlloxan-
dc.subject.keywordStreptozotocin-
dc.subject.keywordRats-
dc.contributor.alternativeNameLee, Duk Chul-
dc.citation.volume26-
dc.citation.number1-
dc.citation.startPage114-
dc.citation.endPage123-
dc.identifier.bibliographicCitationEUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, Vol.26(1) : 114-123, 2005-
dc.date.modified2017-05-04-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers

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