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Serum Levels of Advanced Glycation End Products Are Associated with In-Stent Restenosis in Diabetic Patients

 Eui-Young Choi  ;  Hyuck Moon Kwon  ;  Chul-Woo Ahn  ;  Geun Taek Lee  ;  Boyoung Joung  ;  Bum Kee Hong  ;  Young Won Yoon  ;  Dongsoo Kim  ;  Ki-Hyun Byun  ;  Tae Soo Kang  ;  Se-Jung Yoon  ;  Sung Woo Kwon  ;  Sung-Ju Lee  ;  Jong-Kwan Park  ;  Hyun-Seung Kim 
 YONSEI MEDICAL JOURNAL, Vol.46(1) : 78-85, 2005 
Journal Title
Issue Date
Aged ; Coronary Artery Disease/epidemiology ; Coronary Artery Disease/metabolism* ; Coronary Artery Disease/therapy* ; Coronary Restenosis/epidemiology ; Coronary Restenosis/metabolism* ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/metabolism* ; Female ; Glycation End Products, Advanced/blood* ; Humans ; Male ; Middle Aged ; Risk Factors ; Stents*
Diabetes mellitus ; coronary artery disease ; angioplasty ; restenosis
The formation of advanced glycation end products (AGEs), in various tissues has been known to enhance immunoinflammatory reactions and local oxidant stresses in long standing diabetes. Recently, AGEs have been reported to play a role in neointimal formation in animal models of arterial injury. We attempted to determine whether the serum levels of AGEs are associated with coronary restenosis in diabetic patients. Blood samples were collected from diabetic patients with coronary artery disease undergoing stent implantation and the serum levels of AGEs were analyzed by the fluorescent intensity method. The development of in-stent restenosis (ISR) was evaluated by a 6-month follow-up coronary angiography. A total of 263 target lesions were evaluated, in 203 patients. The ISR rate in the high-AGE (>170 U/ml) group (40.1%) was significantly higher than in the low-AGE group (≤170 U/ml) (19.6%) (p<0.001). Furthermore, multivariate analysis revealed that a high level of serum AGEs is an independent risk factor for the development of ISR (odds ratio, 2.659; 95% CI, 1.431-4.940; p=0.002). The serum levels of AGEs constitute an excellent predictive factor for ISR, and should be one of the guidelines for medical therapy and interventional strategy to prevent ISR in diabetic patients.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Hyuck Moon(권혁문) ORCID logo https://orcid.org/0000-0001-9901-5015
Kim, Hyun Seung(김현승)
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Yoon, Se Jung(윤세정)
Yoon, Young Won(윤영원) ORCID logo https://orcid.org/0000-0002-0907-0350
Joung, Bo Young(정보영) ORCID logo https://orcid.org/0000-0001-9036-7225
Choi, Eui Young(최의영) ORCID logo https://orcid.org/0000-0003-3732-0190
Hong, Bum Kee(홍범기) ORCID logo https://orcid.org/0000-0002-6456-0184
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