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Sevoflurane이 rocuronium의 신경근차단에 대한 neostigmine의 길항작용에 미치는 영향

Other Titles
 The Influence of Sevoflurane on the Antagonism Effect of Neostigmine for Rocuronium-induced Neuromuscular Blockade 
 최승호  ;  김미경  ;  이우경  ;  심연희  ;  신양식 
 KOREAN JOURNAL OF ANESTHESIOLOGY, Vol.48(3) : 247-252, 2005 
Journal Title
Issue Date
antagonism effect ; neostigmine ; neuromuscular blockade ; rocuronium ; sevoflurane
antagonism effect ; neostigmine ; neuromuscular blockade ; rocuronium ; sevoflurane
BACKGROUND: Some volatile anesthetics prolong the spontaneous recovery from neuromuscular blockade, and decrease the effect of neostigmine administrated for neuromuscular recovery. In addition, these effects differ among each volatile anesthetic. The aim of this study was to examine the effect of sevoflurane on the antagonism effect of neostigmine during the recovery period after administering rocuronium.

METHODS: Sixty-five adult patients were randomly allocated into 3 groups, using propofol and alfentanil, sevoflurane, and enflurane for the maintenance of anesthesia. Neuromuscular monitoring was performed using accelomyography. Tracheal intubation was performed at the maximum blockade after administering 0.6 mg/kg rocuronium. The infusion of rocuronium was initiated when a twitch was noticed and the infusion rate of rocuronium was determined to maintain a 15 ± 5% twitch height. The acid-base balance was measured at a constant twitch height, and 20µg/kg neostigmine injection. After neostigmine, the initial twitch height, the maximum twitch height, the onset and duration of neostigmine were measured, and the antagonism effect was calculated as a percentage of the pre-existing twitch depression immediately before administering the neostigmine.

RESULTS: The maximum twitch heights and antagonism effects of the Sevoflurane and Propofol groups were larger than that of the Enflurane group and the durations of the neostigmine effect were longer. The rocuronium infusion rate was significantly higher in the Propofol group than in the other groups.

CONCLUSIONS: The effects of sevoflurane on the antagonism effect and duration of neostigmine were less than enflurane, and there was no difference between sevoflurane and propofol.
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1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Mi Kyeong(김미경)
Shin, Yang Sik(신양식)
Shim, Yon Hee(심연희) ORCID logo https://orcid.org/0000-0003-1921-3391
Choi, Seung Ho(최승호) ORCID logo https://orcid.org/0000-0001-8442-4406
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