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Effect of Angiotensin-converting Enzyme Inhibitors on Phenylephrine Responsiveness in Patients with Valvular Heart Disease

Authors
 HJ KWAK  ;  YL KWAK  ;  YJ OH  ;  YH SHIM  ;  SH KIM  ;  YW HONG 
Citation
 JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, Vol.33(2) : 150-159, 2005 
Journal Title
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
ISSN
 0300-0605 
Issue Date
2005
MeSH
Adjuvants, Anesthesia/pharmacology ; Adult ; Aged ; Androstanols/pharmacology ; Angiotensin-Converting Enzyme Inhibitors/pharmacology* ; Cardiotonic Agents/pharmacology* ; Female ; Heart Diseases/surgery* ; Heart Valves/pathology* ; Humans ; Hypotension/chemically induced ; Male ; Midazolam/pharmacology ; Middle Aged ; Neuromuscular Nondepolarizing Agents/pharmacology ; Phenylephrine/metabolism* ; Rocuronium ; Sufentanil/pharmacology ; Time Factors
Keywords
Angiotensin-Converting enzyme inhibitors ; Hypotension ; Phenylephrine ; Valvular heart disease
Abstract
We studied patients with valvular heart disease to investigate whether chronic preoperative treatment with angiotensin-converting enzyme (ACE) inhibitors modulates the effect of phenylephrine (PE) on anaesthesia-induced hypotension. Sixty-five patients were enrolled in the study and hypotension developed after anaesthesia in 36 (18 in the control group and 18 in the ACE inhibitor group). These patients received PE infusions, which were increased in a stepwise fashion at 10-min intervals. Increased mean arterial pressure due to PE infusion was significant only in the control group. There was no significant difference in pressor response or change in haemodynamic variables with PE infusion between the two groups. Treatment with ACE inhibitors did not increase the incidence of hypotensive episodes or significantly modify pressor response after anaesthesia in patients with valvular heart disease.
Full Text
http://imr.sagepub.com/content/33/2/150.long
DOI
10.1177/147323000503300202
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Kwak, Young Lan(곽영란) ORCID logo https://orcid.org/0000-0002-2984-9927
Shim, Yon Hee(심연희) ORCID logo https://orcid.org/0000-0003-1921-3391
Oh, Young Jun(오영준) ORCID logo https://orcid.org/0000-0002-6258-5695
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/151011
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